ArticleProceedings of the National Academy of Sciences of the United States of America1990
Chemical carcinogenesis: too many rodent carcinogens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 496 citations in OpenAlex.
- The modification of cancer risk by chemicals.Toxicology research · 2021Review
- Effect of High-Dose Topical Minoxidil on Erythrocyte Quality in SKH1 Hairless Mice.Animals : an open access journal from MDPI · 2020Article
- Goodbye to the bioassay.Toxicology research · 2018Review
- Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction.International journal of molecular sciences · 2017Review
- Potential anti-genotoxic effect of sodium butyrate to modulate induction of DNA damage by tamoxifen citrate in rat bone marrow cells.Cytotechnology · 2017Article
- Overview of the Role of Vanillin on Redox Status and Cancer Development.Oxidative medicine and cellular longevity · 2016Review
- A proposal to improve clarity and communication in the EU Classification process for chemicals for carcinogenicity and reproductive and developmental toxicity.Journal of applied toxicology : JAT · 2014Review
- Structure-activity relationship models for rat carcinogenesis and assessing the role mutagens play in model predictivity.SAR and QSAR in environmental research · 2014Article
- Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: in vivo studies.Future medicinal chemistry · 2013Article
- Article
- Of reductionism and the pendulum swing: connecting toxicology and human health.Dose-response : a publication of International Hormesis Society · 2012Article
- Evaluation of the reproductive and developmental risks of caffeine.Birth defects research. Part B, Developmental and reproductive toxicology · 2011Review
- Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C.Journal of oncology · 2011Article
- Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population.Toxicological sciences : an official journal of the Society of Toxicology · 2010Review
- Immunohistochemical analysis of heme oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis.International journal of experimental pathology · 2004Article
- TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva.British journal of cancer · 2003Article
- Homologous Recombination and Its Role in Carcinogenesis.Journal of biomedicine & biotechnology · 2002Article
- Estimating the extent of the health hazard posed by high-production volume chemicals.Environmental health perspectives · 2001Article
- Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).Infection and immunity · 2000Article
- Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.