Evidence map›Paper›PMID 22172057›Full record

SynthesisAnnals of the New York Academy of Sciences2012

The clinical significance of drug craving.

Stephen T Tiffany, Jennifer M Wray

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03412591 (The Efficacy of Suvorexant in the Residential Treatment of Patients With Substance Use Disorder and Insomnia), which is not on this map. Cited by 261 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03412591 phase2 / phase3completednot on this mapstarted 2019, after this paper: background citation

The Efficacy of Suvorexant in the Residential Treatment of Patients With Substance Use Disorder and Insomnia: A Pilot Open Trial

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2019 to 2023Enrolled28ConditionsSleep Disturbance, Craving, Cortisol, HypersecretionArmsSuvorexant 20 mg
3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Craving in gambling disorder: A systematic review.Journal of behavioral addictions · 2023
    Pooled it
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  11. Do lab-based assessments of pretreatment smoking reinforcement and cue-specific craving predict smoking cessation with varenicline?Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Trial
  12. Trial
  13. Relationships Between the Nicotine Metabolite Ratio and Laboratory Assessments of Smoking Reinforcement and Craving Among Adults in a Smoking Cessation Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Trial
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201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephen T TiffanyDepartment of Psychology, University at Buffalo, The State University of New York, Buffalo, New York, USA. stiffany@buffalo.edu
Jennifer M Wray

Funding

Hair Analyses of Nicotine Exposure: Quantifying Low-Level SmokingR01CA120412 · NCI · UNIVERSITY OF UTAH · PI TIFFANY, STEPHEN T · 2007 to 2010
$1.6M
NCI NIH HHS R01 CA120412
6 · The paper itself

Abstract

Although drug craving has received considerable research attention over the past several decades, to date there has been no systematic review of the general clinical significance of craving. This paper presents an overview of measurement issues of particular relevance to a consideration of use of craving in clinical settings. The paper then considers the relevance of craving across a broad array of clinical domains, including diagnosis, prognostic utility, craving as an outcome measure, and the potential value of craving as a direct target of intervention. The paper is both descriptive and prescriptive, informed by the current state of the science on craving with recommendations for the definition of craving, assessment practices, future research, and clinical applications. We conclude that craving has considerable utility for diagnosis and as a clinical outcome, and that findings from future research will likely expand the clinical potential of the craving construct in the domains of prognosis and craving as a treatment target.

Indexed as

AnimalsBehavior, AddictiveHumansInterview, PsychologicalPrognosisSeverity of Illness IndexSubstance-Related Disorders

Identifiers

PMID22172057
PMCPMC4041083

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.