ReviewAnnals of the New York Academy of Sciences2011
Noninvasive imaging of bone microarchitecture.
Review in Annals of the New York Academy of Sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trabecular bone score in adults with type 1 diabetes: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Assessing bone radiodensity and thickness in cochlear implant patients through manual photon-counting CT image segmentation using ITK-SNAP.Scientific reports · 2026Article
- Advances and Shortfalls in MRI Evaluation of Osteoporosis.Radiology · 2023Article
- Age-related reference data of bone microarchitecture, volumetric bone density, and bone strength parameters in a population of healthy Brazilian men: an HR-pQCT study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- On challenges in clinical assessment of hip fracture risk using image-based biomechanical modelling: a critical review.Journal of bone and mineral metabolism · 2021Review
- Imaging of pediatric bone and growth disorders: Of diagnostic workhorses and new horizons.Wiener medizinische Wochenschrift (1946) · 2021Article
- High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures.Journal of clinical medicine · 2021Article
- A Novel MRI Tool for Evaluating Cortical Bone Thickness of the Proximal Femur.Bulletin of the Hospital for Joint Disease (2013) · 2019Article
- Hereditary hypophosphatemic rickets with hypercalciuria: pathophysiology, clinical presentation, diagnosis and therapy.Pflugers Archiv : European journal of physiology · 2019Review
- Weight loss in men in late life and bone strength and microarchitecture: a prospective study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Non-destructive NIR spectral imaging assessment of bone water: Comparison to MRI measurements.Bone · 2017Article
- Age-related reference curves of volumetric bone density, structure, and biomechanical parameters adjusted for weight and height in a population of healthy women: an HR-pQCT study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- A new magnetic resonance-based technique for high-resolution quantification of amorphous and quasi-amorphous structures.Journal of the Royal Society, Interface · 2016Article
- Bone involvement in adult patients affected with Ehlers-Danlos syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations.BoneKEy reports · 2016Review
- Assessment of bone turnover and bone quality in type 2 diabetic bone disease: current concepts and future directions.Bone research · 2016Review
- Bone mass and mineralization in osteogenesis imperfecta.Wiener medizinische Wochenschrift (1946) · 2015Review
- Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study.Bone · 2014Article
- Exploring the relationship between bone density and severity of distal radius fragility fracture in women.Journal of orthopaedic surgery and research · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The noninvasive quantification of peripheral compartment-specific bone microarchitecture is feasible with high-resolution peripheral quantitative computed tomography (HR-pQCT) and high-resolution magnetic resonance imaging (HR-MRI). In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses. Methodical limitations, morphometric parameter definition, and motion artifacts have to be considered to achieve optimal data interpretation from imaging studies. With increasing availability of in vivo high-resolution bone imaging techniques, special emphasis should be put on quality control including multicenter, cross-site validations. Importantly, conclusions from interventional studies investigating the effects of antiosteoporotic drugs on bone microarchitecture should be drawn with care, ideally involving imaging scientists, translational researchers, and clinicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.