ArticleThe journal of physical chemistry. B2012
Reaction kinetics and mechanism of magnetic field effects in cryptochrome.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
- Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.iScience · 2025Article
- European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception.ACS chemical biology · 2025Article
- Understanding the Red Shift in the Absorption Spectrum of the FAD Cofactor in ClCry4 Protein.The journal of physical chemistry. B · 2024Article
- Activation of Cryptochrome 4 from Atlantic Herring.Biology · 2024Article
- Mutational Study of the Tryptophan Tetrad Important for Electron Transfer in European Robin Cryptochrome 4a.ACS omega · 2023Article
- Spin Dynamics of Flavoproteins.International journal of molecular sciences · 2023Review
- Cryptochrome and quantum biology: unraveling the mysteries of plant magnetoreception.Frontiers in plant science · 2023Review
- Across atoms to crossing continents: Application of similarity measures to biological location data.PloS one · 2023Article
- The Static Magnetic Field Regulates the Structure, Biochemical Activity, and Gene Expression of Plants.Molecules (Basel, Switzerland) · 2022Review
- Cryptochromes: Photochemical and structural insight into magnetoreception.Protein science : a publication of the Protein Society · 2021Review
- Article
- Electromagnetic 0.1-100 kHz noise does not disrupt orientation in a night-migrating songbird implying a spin coherence lifetime of less than 10 µs.Journal of the Royal Society, Interface · 2019Article
- Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Atomistic Insights into Cryptochrome Interprotein Interactions.Biophysical journal · 2018Article
- Magnetoreception of Photoactivated Cryptochrome 1 in Electrochemistry and Electron Transfer.ACS omega · 2018Article
- Multiscale description of avian migration: from chemical compass to behaviour modeling.Scientific reports · 2016Article
- Light-dependent magnetoreception in birds: the crucial step occurs in the dark.Journal of the Royal Society, Interface · 2016Article
- Cryptochrome 2 mediates directional magnetoreception in cockroaches.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A Further Investigation of the Effects of Extremely Low Frequency Magnetic Fields on Alkaline Phosphatase and Acetylcholinesterase.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Creatures as varied as mammals, fish, insects, reptiles, and birds have an intriguing sixth sense that allows them to orient themselves in the Earth's magnetic field. Despite decades of study, the physical basis of this magnetic sense remains elusive. A likely mechanism is furnished by magnetically sensitive radical pair reactions occurring in the retina, the light-sensitive part of animal eyes. A photoreceptor, cryptochrome, has been suggested to endow birds with magnetoreceptive abilities as the protein has been shown to exhibit the biophysical properties required for an animal magnetoreceptor to operate properly. Here, we propose a theoretical analysis method for identifying cryptochrome's signaling reactions involving comparison of measured and calculated reaction kinetics in cryptochrome. Application of the method yields an exemplary light-driven reaction cycle, supported through transient absorption and electron-spin-resonance observations together with known facts on avian magnetoreception. The reaction cycle permits one to predict magnetic field effects on cryptochrome activation and deactivation. The suggested analysis method gives insight into structural and dynamic design features required for optimal detection of the geomagnetic field by cryptochrome and suggests further experimental and theoretical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.