ReviewWorld journal of gastroenterology2011
Prevention of peritoneal adhesions: a promising role for gene therapy.
Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- A Bio-Adaptive Janus-Adhesive Dressing with Dynamic Lubrication Overlayer for Prevention of Postoperative Infection and Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions.Pharmaceutics · 2025Review
- Article
- Polyvinylpyrrolidone-Alginate Film Barriers for Abdominal Surgery: Anti-Adhesion Effect in Murine Model.Materials (Basel, Switzerland) · 2023Article
- Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions.Bioactive materials · 2023Review
- Postsurgical Adhesions: Is There Any Prophylactic Strategy Really Working?Journal of clinical medicine · 2023Review
- Article
- An endoscopically compatible fast-gelation powder forms Janus-adhesive hydrogel barrier to prevent postoperative adhesions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sodium butyrate attenuates peritoneal fibroproliferative process in mice.Experimental physiology · 2023Article
- Effect of platelet-rich plasma on postoperative peritoneal inflammation and adhesions.Archives of medical science : AMS · 2021Article
- The effect of Smad2- and Smad3-targeting RNA interference on extracellular matrix synthesis in rat fibroblasts of peritoneal adhesion tissues.American journal of translational research · 2020Article
- The Morphopathogenetic Aspects of Intraabdominal Adhesions in Children under One Year of Age.Medicina (Kaunas, Lithuania) · 2019Article
- Battling adhesions: from understanding to prevention.BMC biomedical engineering · 2019Review
- Targeting lysyl oxidase reduces peritoneal fibrosis.PloS one · 2017Article
- Congenital adhesion band causing small bowel obstruction: What's the difference in various age groups, pediatric and adult patients?BMC surgery · 2016Article
- Article
- Peritoneal adhesion index (PAI): proposal of a score for the "ignored iceberg" of medicine and surgery.World journal of emergency surgery : WJES · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesions are the most frequent complication of abdominopelvic surgery, yet the extent of the problem, and its serious consequences, has not been adequately recognized. Adhesions evolved as a life-saving mechanism to limit the spread of intraperitoneal inflammatory conditions. Three different pathophysiological mechanisms can independently trigger adhesion formation. Mesothelial cell injury and loss during operations, tissue hypoxia and inflammation each promotes adhesion formation separately, and potentiate the effect of each other. Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation. This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions. It explores the promising role of combinatorial gene therapy and vector modifications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.