ReviewWorld journal of gastroenterology2011
Hepatitis B virus infection and the risk of hepatocellular carcinoma.
Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 85 citations in OpenAlex.
- Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine.World journal of gastroenterology · 2015Trial
- Hepatitis B virus protein X promotes survival and loss of hepatocyte identity in a differentiated human liver organoid system.Cell death and differentiation · 2026Article
- Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter.International journal of molecular sciences · 2025Article
- Combined Model for the Diagnosis of Hepatocellular Carcinoma: A Pilot Study Comparing the Liver to Spleen Volume Ratio and Liver Vein to Cava Attenuation.Journal of clinical medicine · 2025Article
- Molecular analysis of HBV pre-core gene mutations in patients co-infected with HIV at a tertiary care hospital in North India.Access microbiology · 2025Article
- Impact of hepatitis B virus infection on the risk of gallbladder polyps: a cohort study.The Korean journal of internal medicine · 2023Article
- Hepatitis B or C viral infection and the risk of cervical cancer.Infectious agents and cancer · 2022Article
- Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: A prospective cohort study.International journal of cancer · 2022Article
- Article
- Occult Hepatitis B Infection in Recent Immigrants to Italy: Occult B Infection in Immigrants.Journal of community health · 2020Article
- Hepatitis B virus perceptions and health seeking behaviors among pregnant women in Uganda: implications for prevention and policy.BMC health services research · 2019Article
- Transforming growth factor-β1 and lysophosphatidic acid activate integrin β6 gene promoter in Hep-3B cells.Oncology letters · 2018Article
- Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.Cellular and molecular gastroenterology and hepatology · 2017Article
- MiRNA-target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis.Scientific reports · 2017Article
- Update on occult hepatitis B virus infection.World journal of gastroenterology · 2016Review
- Observational
- Transcriptional Profiling and miRNA-Target Network Analysis Identify Potential Biomarkers for Efficacy Evaluation of Fuzheng-Huayu Formula-Treated Hepatitis B Caused Liver Cirrhosis.International journal of molecular sciences · 2016Article
- Mechanism of Hepatitis B Virus Persistence in Hepatocytes and Its Carcinogenic Potential.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Review
- Impact of non-oncological factors on tumor recurrence after liver transplantation in hepatocellular carcinoma patients.World journal of gastroenterology · 2016Review
- Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have provided overwhelming evidence for a causal role of chronic hepatitis B virus (HBV) infection in the development of hepatocellular carcinoma (HCC). However, the pathogenesis of HBV infection and carcinogenesis of HBV-associated HCC are still elusive. This review will summarize the current knowledge on the mechanisms involved in HBV-related liver carcinogenesis. The role of HBV in tumor formation appears to be complex, and may involve both direct and indirect mechanisms. Integration of HBV DNA into the host genome occurs at early steps of clonal tumor expansion, and it has been shown to enhance the host chromosomal instability, leading to large inverted duplications, deletions and chromosomal translocations. It has been shown that the rate of chromosomal alterations is increased significantly in HBV-related tumors. Prolonged expression of the viral regulatory HBV x protein may contribute to regulating cellular transcription, protein degradation, proliferation, and apoptotic signaling pathways, and it plays a critical role in the development of hepatocellular carcinoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.