ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
- Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial.Lancet (London, England) · 2017Trial
- A review of the 661W cell line as a tool to facilitate treatment development for retinal diseases.Cell & bioscience · 2025Review
- Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles.International journal of molecular sciences · 2024Article
- Retinal pigment epithelium 65 kDa protein (RPE65): An update.Progress in retinal and eye research · 2022Review
- Current trends in gene therapy for retinal diseases (Review).Experimental and therapeutic medicine · 2022Review
- Voretigene Neparvovec Gene Therapy in Clinical Practice: Treatment of the First Two Italian Pediatric Patients.Translational vision science & technology · 2021Article
- An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease.JCI insight · 2021Article
- Review
- Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration.International journal of molecular sciences · 2020Article
- The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function.Scientific reports · 2019Article
- Selective S Cone Damage and Retinal Remodeling Following Intense Ultrashort Pulse Laser Exposures in the Near-Infrared.Investigative ophthalmology & visual science · 2018Article
- Examining the Role of Cone-expressed RPE65 in Mouse Cone Function.Scientific reports · 2018Article
- Clinical applications of retinal gene therapies.Precision clinical medicine · 2018Review
- Analysis of the bystander effect in cone photoreceptors via a guided neural network platform.Science advances · 2018Article
- Early onset flecked retinal dystrophy associated with new compound heterozygousMolecular vision · 2018Article
- Coexpression of nonvisual opsin, retinal G protein-coupled receptor, and visual pigments in human and bovine cone photoreceptors.Molecular vision · 2018Article
- Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line.Molecular vision · 2018Article
- A subpopulation of activated retinal macrophages selectively migrated to regions of cone photoreceptor stress, but had limited effect on cone death in a mouse model for type 2 Leber congenital amaurosis.Molecular and cellular neurosciences · 2017Article
- Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light.Experimental eye research · 2017Article
- The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones.Visual neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
RPE65 is an abundantly expressed protein within the retinal pigment epithelium (RPE) of the eye that is required for retinoid metabolism to support vision. Its genetic mutations are linked to the congenital disease Leber congenital amaurosis Type 2 (LCA2) characterized by the early onset of central vision loss. Current gene therapy trials have targeted restoration of functional RPE65 within the RPE of these patients with some success. Recent data show that RPE65 is also present within mouse cones to promote function. In this study, we evaluated the presence of RPE65 in human cones and investigated its potential mechanism for supporting cone function in the 661W cone cell line. We found that RPE65 was selectively expressed in human green/red cones but absent from blue cones and mediated ester hydrolysis for photopigment synthesis in vitro. These data suggest that cone RPE65 supports human diurnal vision, potentially enhancing our strategies for treating LCA2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.