ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Searching for presynaptic NMDA receptors in the nucleus accumbens.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Multiplexed neurochemical monitoring reveals glutamate modulates dopamine neurotransmission in the nucleus accumbens.Neurochemistry international · 2026Article
- Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia-reperfusion: An independent component analysis.Frontiers in neuroscience · 2022Article
- Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal.Molecular psychiatry · 2021Article
- AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cortical and Thalamic Interaction with Amygdala-to-Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Critical Role of Basolateral Amygdala-to-Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking.Biological psychiatry · 2020Article
- Altered Corticolimbic Control of the Nucleus Accumbens by Long-term ΔBiological psychiatry · 2020Article
- Ventral Tegmental Area Projection Regulates Glutamatergic Transmission in Nucleus Accumbens.Scientific reports · 2019Article
- A Mini-Review of the Role of Glutamate Transporter in Drug Addiction.Frontiers in neurology · 2019Review
- Review
- Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Prefrontal Cortex to Accumbens Projections in Sleep Regulation of Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.Trends in neurosciences · 2016Review
- Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.The Journal of biological chemistry · 2013Article
- Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens.The Journal of physiology · 2013Article
- Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens.Molecular brain · 2013Article
- Dopamine triggers heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The nucleus accumbens shell (NAc) is a key brain region mediating emotional and motivational learning. In rodent models, dynamic alterations have been observed in synaptic NMDA receptors (NMDARs) within the NAc following incentive stimuli, and some of these alterations are critical for acquiring new emotional/motivational states. NMDARs are prominent molecular devices for controlling neural plasticity and memory formation. Although synaptic NMDARs are predominately located postsynaptically, recent evidence suggests that they may also exist at presynaptic terminals and reshape excitatory synaptic transmission by regulating presynaptic glutamate release. However, it remains unknown whether presynaptic NMDARs exist in the NAc and contribute to emotional and motivational learning. In an attempt to identify presynaptically located NMDARs in the NAc, the present study uses slice electrophysiology combined with pharmacological and genetic tools to examine the physiological role of the putative presynaptic NMDARs in rats. Our results show that application of glycine, the glycine-site agonist of NMDARs, potentiated presynaptic release of glutamate at excitatory synapses on NAc neurons, whereas application of 5,7-dichlorokynurenic acid or 7-chlorokynurenic acid, the glycine-site antagonists of NMDARs, produced the opposite effect. However, these seemingly presynaptic NMDAR-mediated effects could not be prevented by application of d-APV, the glutamate-site NMDAR antagonist, and were still present in the mice in which NMDAR NR1 or NR3 subunits were genetically deleted. Thus, rather than suggesting the existence of presynaptic NMDARs, our results support the idea that an unidentified type of glycine-activated substrate may account for the presynaptic effects appearing to be mediated by NMDARs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.