ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Serotonin-mediated synapsin expression is necessary for long-term facilitation of the Aplysia sensorimotor synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity.International journal of molecular sciences · 2020Article
- Role of p90 ribosomal S6 kinase in long-term synaptic facilitation and enhanced neuronal excitability.Scientific reports · 2020Article
- Targeting epigenetic mechanisms for chronic visceral pain: A valid approach for the development of novel therapeutics.Neurogastroenterology and motility · 2019Review
- A possible structural correlate of learning performance on a colour discrimination task in the brain of the bumblebee.Proceedings. Biological sciences · 2017Article
- Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different.Frontiers in cellular neuroscience · 2017Article
- CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors.Scientific reports · 2016Article
- Stress Enables Reinforcement-Elicited Serotonergic Consolidation of Fear Memory.Biological psychiatry · 2016Article
- Epigenetic mechanisms of chronic pain.Trends in neurosciences · 2015Review
- Modulation of defensive reflex conditioning in snails by serotonin.Frontiers in behavioral neuroscience · 2015Article
- Genomic organization and identification of promoter regions for the BDNF gene in the pond turtle Trachemys scripta elegans.Journal of molecular neuroscience : MN · 2014Article
- The role of serotonin in memory: interactions with neurotransmitters and downstream signaling.Experimental brain research · 2014Review
- When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Pattern and predictability in memory formation: from molecular mechanisms to clinical relevance.Neurobiology of learning and memory · 2013Review
- Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory.Neurobiology of learning and memory · 2013Review
- Histone acetylation: molecular mnemonics on the chromatin.Nature reviews. Neuroscience · 2013Review
- Learning and memory in zebrafish larvae.Frontiers in neural circuits · 2013Review
- Failure of delayed nonsynaptic neuronal plasticity underlies age-associated long-term associative memory impairment.BMC neuroscience · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Serotonin (5-HT)-induced long-term facilitation (LTF) of the Aplysia sensorimotor synapse depends on enhanced gene expression and protein synthesis, but identification of the genes whose expression and regulation are necessary for LTF remains incomplete. In this study, we found that one such gene is synapsin, which encodes a synaptic vesicle-associated protein known to regulate short-term synaptic plasticity. Both synapsin mRNA and protein levels were increased by 5-HT. Upregulation of synapsin protein occurred in presynaptic sensory neurons at neurotransmitter release sites. To investigate the molecular mechanisms underlying synapsin regulation, we cloned the promoter region of Aplysia synapsin, and found that the synapsin promoter contained a cAMP response element (CRE), raising the possibility that the transcriptional activator CRE-binding protein 1 (CREB1) mediates 5-HT-induced regulation of synapsin. Indeed, binding of CREB1 to the synapsin promoter was increased following treatment with 5-HT. Furthermore, increased acetylation of histones H3 and H4 and decreased association of histone deacetylase 5 near the CRE site are consistent with transcriptional activation by CREB1. RNA interference (RNAi) targeting synapsin mRNA blocked the 5-HT-induced increase in synapsin protein levels and LTF; in the absence of 5-HT treatment, basal synapsin levels were unaffected. These results indicate that the 5-HT-induced regulation of synapsin levels is necessary for LTF and that this regulation is part of the cascade of synaptic events involved in the consolidation of memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.