ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Active action potential propagation but not initiation in thalamic interneuron dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- GABAergic Projections from the Pretectum Boost Retinogeniculate Signal Transfer via Disinhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.Neuron · 2024Article
- The type of inhibition provided by thalamic interneurons alters the input selectivity of thalamocortical neurons.Current research in neurobiology · 2024Article
- Intracellular Calcium Responses Encode Action Potential Firing in Spinal Cord Lamina I Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.Nature communications · 2016Article
- Synaptic Contributions to Receptive Field Structure and Response Properties in the Rodent Lateral Geniculate Nucleus of the Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Biophysical Network Modelling of the dLGN Circuit: Different Effects of Triadic and Axonal Inhibition on Visual Responses of Relay Cells.PLoS computational biology · 2016Article
- Effects of Optogenetic Activation of Corticothalamic Terminals in the Motor Thalamus of Awake Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cortical Interneuron Subtypes Vary in Their Axonal Action Potential Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Visual Functions of the Thalamus.Annual review of vision science · 2015Article
- Computer-generated holography enhances voltage dye fluorescence discrimination in adjacent neuronal structures.Neurophotonics · 2015Article
- Contribution of sublinear and supralinear dendritic integration to neuronal computations.Frontiers in cellular neuroscience · 2015Review
- Complex regulation of dendritic transmitter release from thalamic interneurons.Current opinion in neurobiology · 2014Review
- Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Firing of hippocampal neurogliaform cells induces suppression of synaptic inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The subcellular distribution of T-type Ca2+ channels in interneurons of the lateral geniculate nucleus.PloS one · 2014Article
- Synaptic mechanisms of temporal diversity in the lateral geniculate nucleus of the thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Dynamics of intrinsic dendritic calcium signaling during tonic firing of thalamic reticular neurons.PloS one · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inhibitory interneurons of the dorsal lateral geniculate nucleus of the thalamus modulate the activity of thalamocortical cells in response to excitatory input through the release of inhibitory neurotransmitter from both axons and dendrites. The exact mechanisms by which release can occur from dendrites are, however, not well understood. Recent experiments using calcium imaging have suggested that Na/K-based action potentials can evoke calcium transients in dendrites via local active conductances, making the backpropagating action potential a candidate for dendritic neurotransmitter release. In this study, we used high temporal and spatial resolution voltage-sensitive dye imaging to assess the characteristics of dendritic voltage deflections in response to Na/K action potentials in interneurons of the mouse dorsal lateral geniculate nucleus. We found that trains or single action potentials elicited by somatic current injection or local synaptic stimulation rapidly and actively backpropagated throughout the entire dendritic arbor and into the fine filiform dendritic appendages known to release GABAergic vesicles. Action potentials always appeared first in the soma or proximal dendrite in response to somatic current injection or local synaptic stimulation, and the rapid backpropagation into the dendritic arbor depended upon voltage-gated sodium and tetraethylammonium chloride-sensitive potassium channels. Our results indicate that thalamic interneuron dendrites integrate synaptic inputs that initiate action potentials, most likely in the axon initial segment, that then backpropagate with high fidelity into the dendrites, resulting in a nearly synchronous release of GABA from both axonal and dendritic compartments.
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