ArticleJournal of neurophysiology2012
Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- TRPV1-Lineage Somatosensory Fibers Communicate with Taste Neurons in the Mouse Parabrachial Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Variation in the geneAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus.Physiological reports · 2020Article
- Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double-knockout mice.Journal of neurophysiology · 2020Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study.Neuroscience · 2016Article
- Parabrachial Nucleus Contributions to Glucagon-Like Peptide-1 Receptor Agonist-Induced Hypophagia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Mice perceive synergistic umami mixtures as tasting sweet.Chemical senses · 2015Article
- Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Somatostatin and corticotrophin releasing hormone cell types are a major source of descending input from the forebrain to the parabrachial nucleus in mice.Chemical senses · 2014Article
- The importance of the presence of a 5'-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of L-glutamate as assessed psychophysically.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
- Activation of lateral hypothalamus-projecting parabrachial neurons by intraorally delivered gustatory stimuli.Frontiers in neural circuits · 2014Article
- Sweet-bitter and umami-bitter taste interactions in single parabrachial neurons in C57BL/6J mice.Journal of neurophysiology · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Umami is considered to be the fifth basic taste quality and is elicited by glutamate. The mouse is an ideal rodent model for the study of this taste quality because of evidence that suggests that this species, like humans, may sense umami-tasting compounds as unique from other basic taste qualities. We performed single-unit recording of taste responses in the parabrachial nucleus (PbN) of anesthetized C57BL/6J mice to investigate the central representation of umami taste. A total of 52 taste-responsive neurons (22 sucrose-best, 19 NaCl-best, 5 citric acid-best, and 6 quinine-best) were recorded from stimulation period with a large panel of basic and umami-tasting stimuli. No neuron responded best to monopotassium glutamate (MPG) or inosine 5'-monophosphate (IMP), suggesting convergence of input in the central nervous system. Synergism induced by an MPG-IMP mixture was observed in all sucrose-best and some NaCl-best neurons that possessed strong sensitivity to sucrose. In more than half of sucrose-best neurons, the MPG-IMP mixture evoked stronger responses than those elicited by their best stimulus. Furthermore, hierarchical cluster analysis and multidimensional analysis indicated close similarity between sucrose and the MPG-IMP mixture. These results strongly suggest the mixture tastes sweet to mice, a conclusion consistent with previous findings that show bidirectional generalization of conditioned taste aversion between sucrose and umami mixtures, and suppression of taste responses to both sucrose and mixtures by the antisweet polypeptide gurmarin in the chorda tympani nerve. The distribution pattern of reconstructed recording sites of specific neuron types suggested chemotopic organization in the PbN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.