ArticleThe Journal of infectious diseases2012
Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04380402 (Prospective Randomized Open-label Trial of Atorvastatin as Adjunctive Treatment of COVID-19), which is not on this map. Cited by 132 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Randomized Open-label Trial of Atorvastatin as Adjunctive Treatment of COVID-19
Who cites it
132 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- Statins and clinical outcomes with COVID-19: Meta-analyses of observational studies.Diabetes & metabolism · 2021 · on this mapPooled it
- In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis.Pharmacological reports : PR · 2021Pooled it
- Severe influenza treatment guideline.The Korean journal of internal medicine · 2014Guideline
- Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.PloS one · 2012Pooled it
- Randomized Controlled Trial of Atorvastatin in Acute Influenza in the Emergency Department.The western journal of emergency medicine · 2025Trial
- Baseline Statin Use Appears to Protect Against Severe COVID-19.Open forum infectious diseases · 2024Trial
- Effects of Pitavastatin on COVID-19 Incidence and Seriousness Among a Global Cohort of People With HIV.Open forum infectious diseases · 2024Trial
- Trial
- CD151 identifies a cytotoxic CD4 T cell population enriched in people with HIV that later develop cancer.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Impact of statins on short and long term mortality in severe community acquired pneumonia in the intensive care unit.Scientific reports · 2025Article
- Metabolic Hostile Takeover: How Influenza Virus Reprograms Cellular Metabolism for Replication.Viruses · 2025Review
- Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis.PLoS pathogens · 2025Article
- The endothelium at the interface between tissues andClinical microbiology reviews · 2025Review
- Do Statins Affect Viral Infections Encountered by International Travelers?Tropical medicine and infectious disease · 2025Review
- Bridging the gap between CVD and COVID-19: the oxidized LDL hypothesis.Frontiers in medicine · 2025Article
- Impact of statin use on COVID-19 outcomes in hospitalized patients in Saudi Arabia: a retrospective cohort study.Journal of medicine and life · 2024Article
- Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication.iScience · 2024Article
- Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Efficacy of Statin Therapy in Patients with Hospital Admission for COVID-19.Cardiovascular drugs and therapy · 2022Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStatins may have anti-inflammatory and immunomodulatory effects that could reduce the risk of mortality from influenza virus infections.
methodsThe Centers for Disease Control and Prevention's Emerging Infections Program conducts active surveillance for persons hospitalized with laboratory-confirmed influenza in 59 counties in 10 states. We analyzed data for hospitalized adults during the 2007-2008 influenza season to evaluate the association between receiving statins and influenza-related death.
resultsWe identified 3043 patients hospitalized with laboratory-confirmed influenza, of whom 1013 (33.3%) received statins and 151 (5.0%) died within 30 days of their influenza test. Patients who received statins were more likely to be older, male, and white; to suffer from cardiovascular, metabolic, renal, and chronic lung disease; and to have been vaccinated against influenza that season. In a multivariable logistic regression model, administration of statins prior to or during hospitalization was associated with a protective odds of death (adjusted odds ratio, 0.59 [95% confidence interval, .38-.92]) when adjusting for age; race; cardiovascular, lung, and renal disease; influenza vaccination; and antiviral administration.
conclusionsStatin use may be associated with reduced mortality in patients hospitalized with influenza.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.