Evidence map›Paper›PMID 22170936›Full record

ArticleJournal of clinical microbiology2012

Sulfonamide resistance in isolates of Nocardia spp. from a US multicenter survey.

Barbara A Brown-Elliott, Jon Biehle, Patricia S Conville, Samuel Cohen, Michael Saubolle, Den Sussland, Nancy Wengenack, Kimberly Kriel, Linda Bridge, Steven McNulty and 2 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Nocardiosis: A Neglected Disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020
    Pooled it
  2. Review
  3. Article
  4. PulmonaryCase reports in infectious diseases · 2026
    Article
  5. Article
  6. Pathogens (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Updated Review onClinical microbiology reviews · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Barbara A Brown-ElliottUniversity of Texas Health Science Center at Tyler, Tyler, Texas, USA. barbara.elliott@uthct.edu
Jon Biehle
Patricia S Conville
Samuel Cohen
Michael Saubolle
Den Sussland
Nancy Wengenack
Kimberly Kriel
Linda Bridge
Steven McNulty
Ravikiran Vasireddy
Richard J Wallace
The University of Texas Health Science Center at Tyler · USGood Samaritan Medical Center · USCHI Health Creighton University Medical Center - Bergan Mercy · USMayo Clinic · USNational Institutes of Health Clinical Center · USUniversity Pathologists · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent reports of increasing in vitro sulfonamide resistance in Nocardia prompted us to investigate the findings. Despite the reports, there is a paucity of clinical reports of sulfonamide failure in treatment of nocardia disease. We reviewed 552 recent susceptibilities of clinical isolates of Nocardia from six major laboratories in the United States, and only 2% of the isolates were found to have resistant MICs of trimethoprim-sulfamethoxazole and/or sulfamethoxazole. We hypothesize that the discrepancies in the apparent sulfonamide resistance between our study and the previous findings may be associated with difficulty in the laboratory interpretation of in vitro MICs for trimethoprim-sulfamethoxazole and sulfamethoxazole and the lack of quality controls for Nocardia for these agents.

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsNocardiaNocardia InfectionsSulfamethoxazoleSulfonamidesTrimethoprim, Sulfamethoxazole Drug CombinationUnited StatesAnti-Bacterial AgentsSulfamethoxazoleSulfonamidesTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID22170936
PMCPMC3295118
OpenAlexW2096053737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.