ArticleJournal of clinical microbiology2012
Development and validation of a comparative genomic fingerprinting method for high-resolution genotyping of Campylobacter jejuni.
Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 72 citations in OpenAlex.
- Molecular Epidemiological Evidence Implicates Cattle as a Primary Reservoir ofPathogens (Basel, Switzerland) · 2022Article
- Analysis of Campylobacter jejuni Subtype Distribution in the Chicken Broiler Production Continuum: a Longitudinal Examination To Identify Primary Contamination Points.Applied and environmental microbiology · 2021Article
- Dogs and Cats: Reservoirs for Highly DiverseAnimals : an open access journal from MDPI · 2020Article
- Clinically Relevant Campylobacter jejuni Subtypes Are Readily Found and Transmitted within the Cattle Production Continuum but Present a Limited Foodborne Risk.Applied and environmental microbiology · 2020Article
- "These Aren't the Strains You're Looking for": Recovery Bias of CommonFrontiers in microbiology · 2020Article
- Article
- Tetracycline ResistantMicroorganisms · 2019Article
- Whole genome sequencing and metagenomics for outbreak investigation, source attribution and risk assessment of food-borne microorganisms.EFSA journal. European Food Safety Authority · 2019Article
- A strain comparison of Campylobacter isolated from retail poultry and human clinical cases in Atlantic Canada.PloS one · 2019Article
- Critical Orientation in the Jungle of Currently Available Methods and Types of Data for Source Attribution of Foodborne Diseases.Frontiers in microbiology · 2019Review
- Ruminant and chicken: important sources of campylobacteriosis in France despite a variation of source attribution in 2009 and 2015.Scientific reports · 2018Article
- Frequent Implication of Multistress-Tolerant Campylobacter jejuni in Human Infections.Emerging infectious diseases · 2018Article
- Subtype-Specific Selection for Resistance to Fluoroquinolones but Not to Tetracyclines Is Evident in Campylobacter jejuni Isolates from Beef Cattle in Confined Feeding Operations in Southern Alberta, Canada.Applied and environmental microbiology · 2018Article
- Prevalence of ThermophilicFrontiers in microbiology · 2018Article
- Do contamination of and exposure to chicken meat and water drive the temporal dynamics of Campylobacter cases?Epidemiology and infection · 2017Article
- The EpiQuant Framework for Computing Epidemiological Concordance of Microbial Subtyping Data.Journal of clinical microbiology · 2017Article
- Article
- Comparative genomic fingerprinting of Campylobacter: application in routine public health surveillance and epidemiological investigations.Epidemiology and infection · 2017Article
- A Genome-Wide Association Study to Identify Diagnostic Markers for Human PathogenicFrontiers in microbiology · 2017Article
- Genomic insights from whole genome sequencing of four clonal outbreak Campylobacter jejuni assessed within the global C. jejuni population.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter spp. are a leading cause of bacterial gastroenteritis worldwide. The need for molecular subtyping methods with enhanced discrimination in the context of surveillance- and outbreak-based epidemiologic investigations of Campylobacter spp. is critical to our understanding of sources and routes of transmission and the development of mitigation strategies to reduce the incidence of campylobacteriosis. We describe the development and validation of a rapid and high-resolution comparative genomic fingerprinting (CGF) method for C. jejuni. A total of 412 isolates from agricultural, environmental, retail, and human clinical sources obtained from the Canadian national integrated enteric pathogen surveillance program (C-EnterNet) were analyzed using a 40-gene assay (CGF40) and multilocus sequence typing (MLST). The significantly higher Simpson's index of diversity (ID) obtained with CGF40 (ID = 0.994) suggests that it has a higher discriminatory power than MLST at both the level of clonal complex (ID = 0.873) and sequence type (ID = 0.935). High Wallace coefficients obtained when CGF40 was used as the primary typing method suggest that CGF and MLST are highly concordant, and we show that isolates with identical MLST profiles are comprised of isolates with distinct but highly similar CGF profiles. The high concordance with MLST coupled with the ability to discriminate between closely related isolates suggests that CFG40 is useful in differentiating highly prevalent sequence types, such as ST21 and ST45. CGF40 is a high-resolution comparative genomics-based method for C. jejuni subtyping with high discriminatory power that is also rapid, low cost, and easily deployable for routine epidemiologic surveillance and outbreak investigations.
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