ArticleSynapse (New York, N.Y.)2012
Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues.
Article in Synapse (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Frontostriatal and behavioral adaptations to daily sugar-sweetened beverage intake: a randomized controlled trial.The American journal of clinical nutrition · 2017Trial
- Deletion of the sodium leak channel NALCN in dopamine neurons alters D2R-mediated signalling and psychostimulant responsiveness.The Journal of physiology · 2026Article
- AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.Communications biology · 2025Article
- Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice.NPJ science of food · 2024Article
- Value-Driven Adaptations of Mesolimbic Dopamine Release Are Governed by Both Model-Based and Model-Free Mechanisms.eNeuro · 2024Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- Long-TermbioRxiv : the preprint server for biology · 2023Article
- Stimuli predicting high-calorie reward increase dopamine release and drive approach to food in the absence of homeostatic need.Nutritional neuroscience · 2022Article
- "Liking" as an early and editable draft of long-run affective value.PLoS biology · 2022Article
- Cerebellar neurons that curb food consumption.Nature · 2021Article
- Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine.Nutrients · 2021Article
- Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Age-dependent effects of protein restriction on dopamine release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
- Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy.Psychopharmacology · 2020Article
- A Role for GLP-1 in Treating Hyperphagia and Obesity.Endocrinology · 2020Review
- Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine.Scientific reports · 2020Article
- Review
- Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons.Frontiers in psychiatry · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cues that have been paired with food evoke dopamine in nucleus accumbens (NAc) and drive approach behavior. This cue-evoked dopamine signaling could contribute to overconsumption of food. One manner in which individuals try to restrict caloric intake is through the consumption of foods containing artificial (non-nutritive) sweeteners. We were interested in whether cues paired with a non-nutritive sweetener (saccharin) would evoke similar dopamine release as cues paired with a nutritive sweetener (sucrose). We trained food-restricted rats to associate distinct cues with sucrose or saccharin pellets. In the first group of rats, training sessions with each pellet took place on different days, maximizing the opportunity for rats to detect nutritional differences. After training, voltammetry recordings in NAc core revealed that sucrose cues evoked greater phasic dopamine release than saccharin cues. In a second group of rats, on each training day, sucrose and saccharin pellets were presented in pseudorandom order within the same session, to mask nutritional differences. In this condition, the difference in dopamine between sucrose and saccharin cues was attenuated, but not abolished. These results suggest that sucrose-paired cues will more powerfully motivate behavior than saccharin-paired cues. The differing responses to each cue seem to be driven by overall preference with both the nutritional value that the pellets predict as well as other factors, such as taste, contributing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.