ArticleLab on a chip2012
Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Recent Advances in Cardiac Tissue Engineering for the Management of Myocardium Infarction.Cells · 2021Review
- Study of Stem Cells Influence on Cardiac Cells Cultured with a Cyanide-P-Trifluoromethoxyphenylhydrazone in Organ-on-a-Chip System.Biosensors · 2021Article
- Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing.Micromachines · 2021Review
- Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes.iScience · 2019Review
- Microfluidic devices for disease modeling in muscle tissue.Biomaterials · 2019Review
- Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation.Biomaterials · 2019Review
- Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platforms.Future science OA · 2017Article
- Recapitulation of microtissue models connected with real-time readout systems via 3D printing technology.Journal of thoracic disease · 2017Article
- Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering.Molecules (Basel, Switzerland) · 2016Review
- In vitro cardiac tissue models: Current status and future prospects.Advanced drug delivery reviews · 2016Review
- Concise Review: Stem Cell Microenvironment on a Chip: Current Technologies for Tissue Engineering and Stem Cell Biology.Stem cells translational medicine · 2015Review
- Role of the basement membrane in regulation of cardiac electrical properties.Annals of biomedical engineering · 2014Article
- Enzyme-etching technique to fabricate micropatterns of aligned collagen fibrils.Biotechnology letters · 2014Article
- Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment.Lab on a chip · 2014Article
- Three-dimensional filamentous human diseased cardiac tissue model.Biomaterials · 2014Article
- Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field.Analytical chemistry · 2013Review
- Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level.Light, science & applications · 2013Article
- Mesenchymal stem cell-cardiomyocyte interactions under defined contact modes on laser-patterned biochips.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Following myocardial infarction there is an irreversible loss of cardiomyocytes that results in the alteration of electrical propagation in the heart. Restoration of functional electrical properties of the damaged heart muscle is essential to recover from the infarction. While there are a few reports that demonstrate that fibroblasts can form junctions that transmit electrical signals, a potential alternative using the injection of stem cells has emerged as a promising cellular therapy; however, stem-cell electrical conductivity within the cardiac muscle fiber is unknown. In this study, an in vitro cardiac muscle model was established on an MEA-based biochip with multiple cardiomyocytes that mimic cardiac tissue structure. Using a laser beam, stem cells were inserted adjacent to each muscle fiber (cell bridge model) and allowed to form cell-cell contact as determined by the formation of gap junctions. The electrical conductivity of stem cells was assessed and compared with the electrical conductivities of cardiomyocytes and fibroblasts. Results showed that stem cell-myocyte contacts exhibited higher and more stable conduction velocities than myocyte-fibroblast contacts, which indicated that stem cells have higher electrical compatibility with native cardiac muscle fibers than cardiac fibroblasts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.