Evidence map›Paper›PMID 22170369›Full record

Trial reportThe American journal of clinical nutrition2012

Plasma alkylresorcinols as a biomarker of whole-grain food consumption in a large population: results from the WHOLEheart Intervention Study.

Alastair B Ross, Alexandre Bourgeois, Harrison Ndung'u Macharia, Sunil Kochhar, Susan A Jebb, Iain A Brownlee, Chris J Seal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04887584 (Identifying the Role of Pulses in a Healthful Diet), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04887584 nacompletednot on this mapstarted 2022, after this paper: background citation

Identifying the Role of Pulses in a Healthful Diet: Metabolomic Signatures of Dietary Pulses and Their Benefits on Cardiometabolic Risk Factors

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2022 to 2023Enrolled20ConditionsBody WeightArmsControl diet, Low Pulse diet, High Pulse diet
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  13. Metabolomics Based Biomarkers of Green Beans Intake.Molecular nutrition & food research · 2026
    Article
  14. Review
  15. Review
  16. Diversity of plant DNA in stool is linked to dietary quality, age, and household income.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Design Issues in Personalized Nutrition Advice Systems.Journal of medical Internet research · 2023
    Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Alastair B RossNestlé Research Center, Lausanne, Switzerland. alastair.ross@rdls.nestle.com
Alexandre Bourgeois
Harrison Ndung'u Macharia
Sunil Kochhar
Susan A Jebb
Iain A Brownlee
Chris J Seal

Funding

Medical Research Council MC_U105960389
6 · The paper itself

Abstract

backgroundSmall-scale, short-term intervention studies have suggested that plasma alkylresorcinol (AR) concentrations may be biomarkers of whole grain (WG) wheat and rye intakes.

objectiveThe objective was to determine whether plasma AR concentrations reflect self-reported WG food intake in a 16-wk WG intervention study and to establish which phenotypic characteristics influence plasma AR concentrations.

designIn a randomized parallel-group dietary intervention study, 316 overweight and obese participants with a WG intake of <30 g/d were recruited and randomly assigned to 1 of 3 groups: control (no dietary change), intervention 1 (60 g WG/d for 16 wk), or intervention 2 (60 g WG/d for 8 wk followed by 120 g WG/d for 8 wk). Fasting blood samples were collected at baseline, 8 wk, and 16 wk for the measurement of plasma lipids and ARs.

resultsPlasma samples from 266 study completers were analyzed. Total plasma AR concentrations increased with the WG intervention and could be used to distinguish between control subjects and those who consumed 60 or 120 g WG, but not between those who consumed 60 and 120 g WG. Plasma AR concentrations were higher in men, were positively associated with plasma triglyceride concentrations, and were negatively associated with nonesterified fatty acids.

conclusionsPlasma AR concentrations were correlated with WG intake and could be used to distinguish between low- and high-WG consumers. Sex and plasma lipid concentrations independently influenced plasma AR concentrations, although plasma triglycerides may explain higher concentrations in men. This trial is registered as ISRCT no. 83078872.

Indexed as

DietEdible GrainEnergy IntakeSecaleTriticumBiomarkersFatty Acids, NonesterifiedHumansObesityPhenotypeResorcinolsSelf ReportSex FactorsTriglyceridesBiomarkersFatty Acids, NonesterifiedResorcinolsTriglycerides

Identifiers

PMID22170369
PMCPMC3592483

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.