ArticleGenes and immunity2012
Amino acid position 11 of HLA-DRβ1 is a major determinant of chromosome 6p association with ulcerative colitis.
Article in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Novel HLA-DP region susceptibility loci associated with severe acute GvHD.Bone marrow transplantation · 2017Trial
- Review
- Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove.JCI insight · 2023Article
- Analysis of Genomic DNA from Medieval Plague Victims Suggests Long-Term Effect of Yersinia pestis on Human Immunity Genes.Molecular biology and evolution · 2021Article
- Macroscopic to Microscopic - A Case of Crohn's Disease Progressing to Collagenous Colitis.Cureus · 2021Article
- HLA-DRB1 Amino Acid Positions and Residues Associated with Antibody-positive Rheumatoid Arthritis in Black South Africans.The Journal of rheumatology · 2019Article
- Genetic associations of inflammatory bowel disease in a South Asian population.World journal of clinical cases · 2018Article
- Development of an AmpliSeqFrontiers in pharmacology · 2018Article
- Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.Inflammatory bowel diseases · 2017Article
- The genetics of human autoimmune disease: A perspective on progress in the field and future directions.Journal of autoimmunity · 2015Review
- Genetic architectures of seropositive and seronegative rheumatic diseases.Nature reviews. Rheumatology · 2015Review
- A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.American journal of human genetics · 2015Article
- High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.Nature genetics · 2015Article
- Dysbiotic events in gut microbiota: impact on human health.Nutrients · 2014Review
- Gene-gene and gene-environment interactions in ulcerative colitis.Human genetics · 2014Article
- A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease.Inflammatory bowel diseases · 2013Article
- Article
- Major histocompatibility complex genomics and human disease.Annual review of genomics and human genetics · 2013Review
- Article
- Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.Human molecular genetics · 2012Article
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
Abstract
The major histocompatibility complex (MHC) on chromosome 6p is an established risk locus for ulcerative colitis (UC) and Crohn's disease (CD). We aimed to better define MHC association signals in UC and CD by combining data from dense single-nucleotide polymorphism (SNP) genotyping and from imputation of classical human leukocyte antigen (HLA) types, their constituent SNPs and corresponding amino acids in 562 UC, 611 CD and 1428 control subjects. Univariate and multivariate association analyses were performed, controlling for ancestry. In univariate analyses, absence of the rs9269955 C allele was strongly associated with risk for UC (P = 2.67 × 10(-13)). rs9269955 is a SNP in the codon for amino acid position 11 of HLA-DRβ1, located in the P6 pocket of the HLA-DR antigen binding cleft. This amino acid position was also the most significantly UC-associated amino acid in omnibus tests (P = 2.68 × 10(-13)). Multivariate modeling identified rs9269955-C and 13 other variants in best predicting UC vs control status. In contrast, there was only suggestive association evidence between the MHC and CD. Taken together, these data demonstrate that variation at HLA-DRβ1, amino acid 11 in the P6 pocket of the HLA-DR complex antigen binding cleft is a major determinant of chromosome 6p association with UC.
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