Evidence map›Paper›PMID 22170177›Full record

Trial reportNeurosurgical review2012

Effect of magnesium sulfate therapy on patients with aneurysmal subarachnoid hemorrhage using serum S100B protein as a prognostic marker.

Tamer Hassan, Mahmoud Nassar, Sherif Mohammed Elhadi, Wafa Kamel Radi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurosurgical review, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2014
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tamer HassanDepartment of Neurosurgery, Alexandria University School of Medicine, Elazarita, Shambeleon Street, Alexandria, Egypt. Neurocatheter@yahoo.com
Mahmoud Nassar
Sherif Mohammed Elhadi
Wafa Kamel Radi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium, one of the essential trace elements, plays important roles in maintaining both normal cellular and body functions. S100 calcium-binding protein B (S100B) has been used as a marker of glial damage in several neurological disorders. Thirty patients with ruptured intracranial aneurysms treated by clipping are included. The patients were randomized within 4 days after the attack of hemorrhage. The patients were divided into two groups with 15 patients in each group. Group I received magnesium infusion within 4 days. Group II is the control group. World Federation of Neurological Surgeons, Fisher, and Glasgow outcome scores are evaluated at an intensive care unit in addition to 3 months clinical follow-up evaluation. Samplings of serum S100B were performed on admission and on postoperative days 1, 3, and 7. There is a statistically significant difference between both groups as regards the second reading of the S100B (day 1 postoperative; P < 0.05). There is no statistically significant difference between both groups as regards outcome at 3 months using clinical status and S100B values. There is a tendency in the magnesium group to have better outcomes. Further studies with more number of patients with subarachnoid hemorrhage are needed to determinate the accuracy of S100B protein as a prognostic marker and of magnesium sulfate as a neuroprotector.

Indexed as

AdultAgedAged, 80 and overBiomarkersFemaleHumansMagnesium SulfateMaleMiddle AgedNerve Growth FactorsS100 Calcium Binding Protein beta SubunitS100 ProteinsSubarachnoid HemorrhageTreatment OutcomeVasospasm, IntracranialBiomarkersMagnesium SulfateNerve Growth FactorsS100B protein, humanS100 Calcium Binding Protein beta SubunitS100 Proteins

Identifiers

PMID22170177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.