Evidence map›Paper›PMID 22170033›Full record

ReviewClinical rheumatology2012

Development of lepromatous leprosy following etanercept treatment for arthritis.

Charalampos Lydakis, Despina Ioannidou, Irini Koumpa, Elpida Giannikaki, Evaggelos Thalassinos, Eleni Krasoudaki, Spiros Miyakis

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Clinical rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Biologics in Leprosy: A Systematic Review and Case Report.The American journal of tropical medicine and hygiene · 2020
    Pooled it
  3. Psoriasis and Leprosy: An Arcane Relationship.Journal of inflammation research · 2023
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Charalampos Lydakis2nd Medical Department, Venizelion General Hospital of Heraklion, Heraklion, Greece. hlydakis@yahoo.gr
Despina Ioannidou
Irini Koumpa
Elpida Giannikaki
Evaggelos Thalassinos
Eleni Krasoudaki
Spiros Miyakis
The General Hospital of Heraklion "Venizeleio-Pananio" · GRCentre for Technological Research of Crete · GRPapageorgiou General Hospital · GRUniversity Hospital of Heraklion · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a patient treated with etanercept (TNF-a antagonist) for psoriatic arthritis, who then developed clinical symptoms of lepromatous leprosy. She presented with multiple erythematous plaques on trunk, face and extremities, saddle nose deformity, alopecia, articular deformities of the feet and peroneal neuropathy. The clinical suspicion of Hansen's Disase was confirmed by the biopsy findings (lepromatous leprosy). On further questioning, the patient stated that her father was diagnosed with leprosy 70 years ago and had spent some years in a leper colony in Spinalonga island in Southern Greece in the 1940s. This first report of Hansen's disease after administration of etanercept highlights the need of careful risk assessment of patients for whom antiTNF treatment is planned.

Indexed as

AgedAntirheumatic AgentsArthritis, PsoriaticEtanerceptHumansImmunoglobulin GImmunosuppressive AgentsLeper ColoniesLeprosyLeprosy, LepromatousReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alphaAntirheumatic AgentsEtanerceptImmunoglobulin GImmunosuppressive AgentsReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alpha

Identifiers

PMID22170033
OpenAlexW2013780378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.