ArticleBiomaterials2012
The effect of vitronectin on the differentiation of embryonic stem cells in a 3D culture system.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Synthetic thermoresponsive scaffolds for the expansion and differentiation of human pluripotent stem cells into cardiomyocytes.RSC advances · 2025Article
- Review
- The impact of extracellular matrix proteins on bovine fibro-adipogenic progenitor cell adhesion, proliferation, and differentiation in vitro.Physiological reports · 2025Article
- Preparation and Characterization of Nanofiber Coatings on Bone Implants for Localized Antimicrobial Activity Based on Sustained Ion Release and Shape-Preserving Design.Materials (Basel, Switzerland) · 2024Article
- Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair.Frontiers in bioengineering and biotechnology · 2023Review
- A chemically-defined plastic scaffold for the xeno-free production of human pluripotent stem cells.Scientific reports · 2022Article
- Rapid structural regulation, apatite-inducing mechanism andRSC advances · 2021Article
- Functional Vascular Tissue Engineering Inspired by Matricellular Proteins.Frontiers in cardiovascular medicine · 2019Review
- Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate.Stem cells international · 2018Review
- The role of laminins in cartilaginous tissues: from development to regeneration.European cells & materials · 2017Review
- Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis.Circulation research · 2016Review
- Porous nanofibrous poly(L-lactic acid) scaffolds supporting cardiovascular progenitor cells for cardiac tissue engineering.Acta biomaterialia · 2015Article
- Abi3bp regulates cardiac progenitor cell proliferation and differentiation.Circulation research · 2014Article
- Microenvironment influences vascular differentiation of murine cardiovascular progenitor cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2014Article
- Article
- Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings.International journal of nanomedicine · 2014Article
- Article
- Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations.ISRN tissue engineering · 2013Article
- Regeneration in heart disease-Is ECM the key?Life sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
While stem cell niches in vivo are complex three-dimensional (3D) microenvironments, the relationship between the dimensionality of the niche to its function is unknown. We have created a 3D microenvironment through electrospinning to study the impact of geometry and different extracellular proteins on the development of cardiac progenitor cells (Flk-1(+)) from resident stem cells and their differentiation into functional cardiovascular cells. We have investigated the effect of collagen IV, fibronectin, laminin and vitronectin on the adhesion and proliferation of murine ES cells as well as the effects of these proteins on the number of Flk-1(+) cells cultured in 2D conditions compared to 3D system in a feeder free condition. We found that the number of Flk-1(+) cells was significantly higher in 3D scaffolds coated with laminin or vitronectin compared to colIV-coated scaffolds. Our results show the importance of defined culture systems in vitro for studying the guided differentiation of pluripotent embryonic stem cells in the field of cardiovascular tissue engineering and regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.