ArticleCurrent biology : CB2011
Tor complex 1 controls telomere length by affecting the level of Ku.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.Genetics · 2026Article
- NADCommunications biology · 2025Article
- Telomeres are shorter in wild Saccharomyces cerevisiae isolates than in domesticated ones.Genetics · 2023Article
- Cellular enlargement - A new hallmark of aging?Frontiers in cell and developmental biology · 2022Review
- A comparative analysis of telomere length maintenance circuits in fission and budding yeast.Frontiers in genetics · 2022Article
- The effect of rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance.Aging · 2020Article
- Telomere attrition: metabolic regulation and signalling function?Biology letters · 2019Article
- Frequent ploidy changes in growing yeast cultures.Current genetics · 2018Review
- Aneuploidy as a mechanism of adaptation to telomerase insufficiency.Current genetics · 2016Article
- Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.Nucleic acids research · 2016Article
- Telomere dynamics may link stress exposure and ageing across generations.Biology letters · 2015Review
- Cell populations can use aneuploidy to survive telomerase insufficiency.Nature communications · 2015Article
- Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2015Article
- Genome-wide studies of telomere biology in budding yeast.Microbial cell (Graz, Austria) · 2014Review
- Nature vs nurture: interplay between the genetic control of telomere length and environmental factors.Cell cycle (Georgetown, Tex.) · 2013Article
- Environmental stresses disrupt telomere length homeostasis.PLoS genetics · 2013Article
- The fine line between lifespan extension and shortening in response to caloric restriction.Nucleus (Austin, Tex.)Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres are specialized DNA-protein structures at the ends of eukaryotic chromosomes. Telomeric DNA is synthesized by telomerase, which is expressed only at the early stages of development [1, 2]. To become malignant, any cell has to be able to replenish telomeres [3]. Thus, understanding how telomere length is monitored has significant medical implications, especially in the fields of aging and cancer. In yeast, telomerase is constitutively active. A large network of genes participates in controlling telomere length [4-8]. Tor1 and Tor2 (targets of rapamycin [9]) are two similar kinases that regulate cell growth [10]. Both can be found as part of the TOR complex 1 (TORC1 [11]), which coordinates the response to nutrient starvation and is sensitive to rapamycin [12]. The rapamycin-insensitive TOR complex 2 (TORC2) contains only Tor2 and regulates actin cytoskeleton polarization [13]. Here we provide evidence for a role of TORC1 in telomere shortening upon starvation in yeast cells. The TORC1 signal is transduced by the Gln3/Gat1/Ure2 pathway, which controls the levels of the Ku heterodimer, a telomere regulator. We discuss the potential implications for the usage of rapamycin as a therapeutic agent against cancer and the effect that calorie restriction may have on telomere length.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.