ArticleScience signaling2011
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Reversible control of kinase signaling through chemical-induced dephosphorylation.Communications biology · 2024Article
- Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis.Nature communications · 2024Article
- Calcium influx promotes PLEKHG4B localization to cell-cell junctions and regulates the integrity of junctional actin filaments.Molecular biology of the cell · 2024Article
- PIPCommunications biology · 2022Article
- Methods to study phosphoinositide regulation of ion channels.Methods in enzymology · 2021Article
- Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis.Frontiers in cell and developmental biology · 2021Review
- Rapamycin-induced protein dimerization as a tool formicroPublication biology · 2018Article
- Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides.Current opinion in cell biology · 2018Review
- Cortical Actin Dynamics in Endothelial Permeability.Current topics in membranes · 2018Article
- Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cells.Molecular autism · 2018Article
- Mice Deficient inMolecular and cellular biology · 2017Article
- Altering the threshold of an excitable signal transduction network changes cell migratory modes.Nature cell biology · 2017Article
- Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides.The Journal of cell biology · 2016Article
- Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.Developmental cell · 2015Article
- Detection and manipulation of phosphoinositides.Biochimica et biophysica acta · 2015Review
- Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation.Nature cell biology · 2015Article
- The role of phosphoinositides in synapse function.Molecular neurobiology · 2014Review
- Article
- NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.The EMBO journal · 2014Article
- Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A limited set of phosphoinositide membrane lipids regulate diverse cellular functions including proliferation, differentiation, and migration. We developed two techniques based on rapamycin-induced protein dimerization to rapidly change the concentration of plasma membrane phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. First, using a membrane-recruitable form of PI(4)P 5-kinase, we increased PI(4,5)P(2) synthesis from phosphatidylinositol 4-phosphate [PI(4)P] and found that COS-7, HeLa, and human embryonic kidney 293 cells formed bundles of motile actin filaments known as actin comets. In contrast, a second technique that increased the concentration of PI(4,5)P(2) without consuming PI(4)P induced membrane ruffles. These distinct phenotypes were mediated by dynamin-mediated vesicular trafficking and mutually inhibitory crosstalk between the small guanosine triphosphatases Rac and RhoA. Our results indicate that the effect of PI(4,5)P(2) on actin reorganization depends on the abundance of other phosphoinositides, such as PI(4)P. Thus, combinatorial regulation of phosphoinositide concentrations may contribute to the diversity of phosphoinositide functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.