ArticleInvestigative ophthalmology & visual science2012
Changes in human meibum lipid composition with age using nuclear magnetic resonance spectroscopy.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model.International journal of molecular sciences · 2019Pooled it
- Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy.Investigative ophthalmology & visual science · 2026Article
- Comparative Analysis of Age-Associated Changes in Meibum Composition, Distribution, and Function in Mice With Altered Hyaluronan Expression.Investigative ophthalmology & visual science · 2025Article
- Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors.Archives of toxicology · 2024Review
- Recent advances in age-related meibomian gland dysfunction (ARMGD).The ocular surface · 2023Review
- Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.International journal of molecular sciences · 2023Article
- Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.Investigative ophthalmology & visual science · 2023Article
- The Riddle of Cetuximab-Related Skin Toxicity:Cancers · 2022Article
- Effects of Aging on Human Meibum.Investigative ophthalmology & visual science · 2021Article
- Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease.Investigative ophthalmology & visual science · 2021Article
- The Properties and Role ofThe Journal of organic chemistry · 2021Article
- Protective Role of Sphingomyelin in Eye Lens Cell Membrane Model against Oxidative Stress.Biomolecules · 2021Article
- Comprehensive profiling of Asian and Caucasian meibomian gland secretions reveals similar lipidomic signatures regardless of ethnicity.Scientific reports · 2020Article
- Changes in meibum composition following plaque bachytherapy for choroidal melanoma.BMJ open ophthalmology · 2020Article
- Lipid Saturation and the Rheology of Human Tear Lipids.International journal of molecular sciences · 2019Article
- Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2019Article
- Human meibum chain branching variability with age, gender and meibomian gland dysfunction.The ocular surface · 2019Article
- Age-associated changes in human tear proteome.Clinical proteomics · 2019Article
- Effect of Refresh PlusClinical ophthalmology (Auckland, N.Z.) · 2019Article
- Insights into Tear Film Stability from Babies and Young Adults: A Study of Human Meibum Lipid Conformation and Rheology.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeHuman tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability.
methods(1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired.
resultsCompared with meibum from adolescents and adults, meibum from infants and children contains less CH(3) and C═C groups and an increased aldehyde-to-lipid hydroperoxide ratio.
conclusionsIt is reasonable that tear film stability is higher in infants than in adults. Their meibum contains less CH(3) and C═C groups and higher levels of protein, and as a result, the lipid is more ordered because of the tighter and stronger lipid-lipid interactions. For water to evaporate, it must first pass through the tight lipid-lipid barrier. For tears to break up, lipid-lipid interactions must be broken. It is reasonable that because the lipid-lipid interactions are stronger in infants' and children's tears compared with those of adolescents and adults, the tear film in the younger groups is more stable and provides a better barrier to evaporation than does the tear film of adults. Lipid saturation could be the critical feature in meibum that stabilizes tears in infants.
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