Evidence map›Paper›PMID 22168439›Full record

ReviewThe Biochemical journal2012

Vitamin D and cancer: a review of molecular mechanisms.

James C Fleet, Marsha DeSmet, Robert Johnson, Yan Li

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Biochemical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 19 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 19 syntheses or guidelines pooled it, 406 citations in OpenAlex.

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  7. Efficacy of vitamin DAgeing research reviews · 2023
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  11. Association Between Vitamin D Supplementation and Statin-Associated Muscle Symptoms: A Systematic Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
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  18. Vitamin D supplementation for prevention of cancer in adults.The Cochrane database of systematic reviews · 2014
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147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

James C FleetPurdue University Interdisciplinary Life Sciences Program, Purdue University, West Lafayette, IN 47907-2059, USA.
Marsha DeSmet
Robert Johnson
Yan Li
Purdue University West Lafayette · US

Funding

Vitamin D Status and Prostate CancerR01CA101113 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI FLEET, JAMES C. · 2004 to 2008
$1.9M
NCI NIH HHS CA10113NCI NIH HHS R01 CA101113
6 · The paper itself

Abstract

The population-based association between low vitamin D status and increased cancer risk can be inconsistent, but it is now generally accepted. These relationships link low serum 25OHD (25-hydroxyvitamin D) levels to cancer, whereas cell-based studies show that the metabolite 1,25(OH)2D (1,25-dihydroxyvitamin D) is a biologically active metabolite that works through vitamin D receptor to regulate gene transcription. In the present review we discuss the literature relevant to the molecular events that may account for the beneficial impact of vitamin D on cancer prevention or treatment. These data show that although vitamin D-induced growth arrest and apoptosis of tumour cells or their non-neoplastic progenitors are plausible mechanisms, other chemoprotective mechanisms are also worthy of consideration. These alternative mechanisms include enhancing DNA repair, antioxidant protection and immunomodulation. In addition, other cell targets, such as the stromal cells, endothelial cells and cells of the immune system, may be regulated by 1,25(OH)2D and contribute to vitamin D-mediated cancer prevention.

Indexed as

Gene Expression RegulationHumansNeoplasmsReceptors, CalcitriolSignal TransductionVitamin DVitamin D DeficiencyVitamins1,25-dihydroxyvitamin DReceptors, CalcitriolVitamin DVitamins

Identifiers

PMID22168439
PMCPMC4572477
OpenAlexW2018730905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.