SynthesisBMC geriatrics2011
Exposure to general anesthesia and risk of Alzheimer's disease: a systematic review and meta-analysis.
Synthesis in BMC geriatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045004 (Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia (POCD-MRI)
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Comparison of regional vs. general anesthesia on the risk of dementia: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Relationship between Surgery under General Anesthesia and the Development of Dementia: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis.BMC anesthesiology · 2018Pooled it
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- Epidemiology and Risk Factors Characteristics of Alzheimer's Disease in Southwestern China: A Cross-Sectional Study.Clinical interventions in aging · 2025Article
- Let-7b-TLR7 Signaling Axis Contributes to the Anesthesia/Surgery-Induced Cognitive Impairment.Molecular neurobiology · 2024Article
- The impact of surgery with general anesthesia on cognitive function and putamen volume: a cross-sectional study among older adults.Frontiers in aging neuroscience · 2024Article
- Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population.Scientific reports · 2023Article
- Dementia risk after major elective surgery based on the route of anaesthesia: A propensity score-matched population-based cohort study.EClinicalMedicine · 2023Article
- Anesthesia promotes acute expression of genes related to Alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy.Molecular medicine (Cambridge, Mass.) · 2022Article
- Extended anesthesia exposure for abdominal and pelvic procedures in older adults with colorectal cancer: Associations with chart dementia diagnoses.Experimental gerontology · 2022Article
- Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppMolecular brain · 2022Article
- Risk of Dementia According to Surgery Type: A Nationwide Cohort Study.Journal of personalized medicine · 2022Article
- An Update on Postoperative Cognitive Dysfunction Following Cardiac Surgery.Frontiers in psychiatry · 2022Review
- Postoperative Cognitive Dysfunction and Alzheimer's Disease: A Transcriptome-Based Comparison of Animal Models.Frontiers in aging neuroscience · 2022Article
- Carotid revascularization and cognitive impairment: the neglected role of cerebral small vessel disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Risk of Dementia in Patients Who Underwent Surgery under Neuraxial Anesthesia: A Nationwide Cohort Study.Journal of personalized medicine · 2021Article
- Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia.Journal of personalized medicine · 2021Article
- Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice.Acta neurologica Belgica · 2021Article
- Risk factors and predictive value of perioperative neurocognitive disorders in elderly patients with gastrointestinal tumors.BMC anesthesiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlzheimer's disease (AD) is common among older adults and leads to significant disability. Volatile anesthetic gases administered during general anesthesia (GA) have been hypothesized to be a risk factor for the development of AD. The objective of this study is to systematically review the association between exposure to GA and risk of AD.
methodsWe searched electronic databases including MEDLINE, Embase, and Google scholar for observational studies examining the association between exposure to GA and risk of AD. We examined study quality using a modified version of the Newcastle-Ottawa risk of bias assessment for observational studies. We used standard meta-analytic techniques to estimate pooled odds ratios (OR) and 95% confidence intervals (CI). Subgroup and sensitivity analyses were undertaken to evaluate the robustness of the findings.
resultsA total of 15 case-control studies were included in the review. No cohort studies were identified that met inclusion criteria. There was variation in the methodological quality of included studies. There was no significant association between any exposure to GA and risk of AD (pooled OR: 1.05; 95% CI: 0.93 - 1.19, Z = 0.80, p = 0.43). There was also no significant association between GA and risk of AD in several subgroup and sensitivity analyses.
conclusionsA history of exposure to GA is not associated with an increased risk of AD although there are few high-quality studies in this area. Prospective cohort studies with long-term follow-up or randomized controlled trials are required to further understand the association between GA and AD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.