ArticleAnesthesia and analgesia2012
Determination of minimum alveolar concentration for isoflurane and sevoflurane in a rodent model of human metabolic syndrome.
Article in Anesthesia and analgesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 19 citations in OpenAlex.
- Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study.Anesthesiology · 2025Article
- Article
- Prehabilitative exercise hastens recovery from isoflurane in diabetic and non-diabetic rats.Neuroscience letters · 2021Article
- Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- General Anesthesia Does Not Have Persistent Effects on Attention in Rodents.Frontiers in behavioral neuroscience · 2019Article
- Characterization of Brain-Heart Interactions in a Rodent Model of Sepsis.Molecular neurobiology · 2017Article
- Paradoxical Emergence: Administration of Subanesthetic Ketamine during Isoflurane Anesthesia Induces Burst Suppression but Accelerates Recovery.Anesthesiology · 2017Article
- Combining isoflurane anesthesia with midazolam and butorphanol in rats.Experimental animals · 2016Article
- Reduced Nav1.6 Sodium Channel Activity in Mice Increases In Vivo Sensitivity to Volatile Anesthetics.PloS one · 2015Article
- Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome.Sleep · 2014Article
- Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention.Journal of visualized experiments : JoVE · 2013Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundMorbid obesity affects the pharmacokinetics and pharmacodynamics of anesthetics, which may result in inappropriate dosing. We hypothesized that obesity significantly alters the minimum alveolar concentration (MAC) for isoflurane and sevoflurane. To test this hypothesis, we used a rodent model of human metabolic syndrome developed through artificial selection for inherent low aerobic capacity runners (LCR) and high aerobic capacity runners (HCR). The LCR rats are obese, display phenotypes homologous to those characteristic of human metabolic syndrome, and exhibit low running endurance. In contrast, HCR rats have high running endurance and are characterized by improved cardiovascular performance and overall health.
methodsMale and female LCR (n = 10) and HCR (n = 10) rats were endotracheally intubated and maintained on mechanical ventilation with either isoflurane or sevoflurane. A bracketing design was used to determine MAC; sensory stimulation was induced by tail clamping. An equilibration period of 30 minutes was provided before and between the consecutive tail clamps. Two-tailed parametric (unpaired t test) and nonparametric (Mann-Whitney test) statistics were used for the comparison of MAC between LCR and HCR rats. The data are reported as mean ± sd along with the 95% confidence interval. A P value of <0.05 was considered statistically significant.
resultsThe MAC for isoflurane in LCR rats (1.52% ± 0.13%) was similar to previously reported isoflurane-MAC for normal rats (1.51% ± 0.12%). The HCR rats showed a significantly higher isoflurane-MAC (1.90% ± 0.19%) than did the LCR rats (1.52% ± 0.13%) (P = 0.0001). The MAC for sevoflurane was not significantly different between LCR and HCR rats and was similar to the previously published sevoflurane-MAC for normal rats (2.4% ± 0.30%). There was no influence of sex on the MAC of either isoflurane or sevoflurane.
conclusionObesity and associated comorbidities do not affect anesthetic requirements as measured by MAC in a rodent model of metabolic syndrome. By contrast, high aerobic capacity is associated with a higher MAC for isoflurane and may be a risk factor for subtherapeutic dosing.
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