ArticleThe European physical journal. E, Soft matter2011
Conformational dynamics and internal friction in homopolymer globules: equilibrium vs. non-equilibrium simulations.
Article in The European physical journal. E, Soft matter, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The role of memory-dependent friction and solvent viscosity in isomerization kinetics in viscogenic media.Nature communications · 2024Article
- Internal tension in a collapsed polymer under shear flow and the connection to enzymatic cleavage of von Willebrand factor.The European physical journal. E, Soft matter · 2016Article
- How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Shear-enhanced adsorption of a homopolymeric globule mediated by surface catch bonds.The European physical journal. E, Soft matter · 2015Article
- Optical tweezers reveal force plateau and internal friction in PEG-induced DNA condensation.European biophysics journal : EBJ · 2014Article
- Confinement-dependent friction in peptide bundles.Biophysical journal · 2013Article
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Authors and funding
4 authors.
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Abstract
We study the conformational dynamics within homopolymer globules by solvent-implicit Brownian dynamics simulations. A strong dependence of the internal chain dynamics on the Lennard-Jones cohesion strength ε and the globule size N (G) is observed. We find two distinct dynamical regimes: a liquid-like regime (for ε < ε(s) with fast internal dynamics and a solid-like regime (for ε > ε(s) with slow internal dynamics. The cohesion strength ε(s) of this freezing transition depends on N (G) . Equilibrium simulations, where we investigate the diffusional chain dynamics within the globule, are compared with non-equilibrium simulations, where we unfold the globule by pulling the chain ends with prescribed velocity (encompassing low enough velocities so that the linear-response, viscous regime is reached). From both simulation protocols we derive the internal viscosity within the globule. In the liquid-like regime the internal friction increases continuously with ε and scales extensive in N (G) . This suggests an internal friction scenario where the entire chain (or an extensive fraction thereof) takes part in conformational reorganization of the globular structure.
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