SynthesisAmerican journal of physiology. Endocrinology and metabolism2012
Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast.
Synthesis in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.Obesity (Silver Spring, Md.) · 2018Trial
- The regulation of intrahepatic fatty acid partitioning within the human liver: the effect of sex.Clinical science (London, England : 1979) · 2026Review
- Fat Oxidation, But Not Subcutaneous Adipose Tissue Lipolysis, Differs Between Males and Females During a Treadmill-Based Heat Tolerance Test.European journal of sport science · 2026Article
- The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation.Experimental physiology · 2025Review
- Diverting hepatic lipid fluxes with lifestyles revision and pharmacological interventions as a strategy to tackle steatotic liver disease (SLD) and hepatocellular carcinoma (HCC).Nutrition & metabolism · 2024Review
- Impaired Mitochondrial Respiration in Upper Compared to Lower Body Differentiated Human Adipocytes and Adipose Tissue.The Journal of clinical endocrinology and metabolism · 2024Article
- Article
- Role of prior feeding status in mediating the effects of exercise on blood glucose kinetics.American journal of physiology. Cell physiology · 2023Review
- Measuring and estimating insulin resistance in clinical and research settings.Obesity (Silver Spring, Md.) · 2022Review
- Effects of SGLT2 inhibition on lipid transport in adipose tissue in type 2 diabetes.Endocrine connections · 2022Article
- Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound.Adipocyte · 2021Article
- Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal.Physiological reports · 2021Article
- Review
- Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets.International journal of molecular sciences · 2020Review
- Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats.International journal of obesity (2005) · 2020Article
- Lactate production is a prioritized feature of adipocyte metabolism.The Journal of biological chemistry · 2020Article
- A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data.PLoS computational biology · 2019Article
- Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity.Obesity science & practice · 2019Article
- CD24 is required for regulating gene expression, but not glucose uptake, during adipogenesis.Adipocyte · 2018Article
- Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability.Journal of diabetes research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Subcutaneous abdominal adipose tissue is one of the largest fat depots and contributes the major proportion of circulating nonesterified fatty acids (NEFA). Little is known about aspects of human adipose tissue metabolism in vivo other than lipolysis. Here we collated data from 331 experiments in 255 healthy volunteers over a 23-year period, in which subcutaneous abdominal adipose tissue metabolism was studied by measurements of arterio-venous differences after an overnight fast. NEFA and glycerol were released in a ratio of 2.7:1, different (P < 0.001) from the value of 3.0 that would indicate no fatty acid re-esterification. Fatty acid re-esterification was 10.2 ± 1.4%. Extraction of triacylglycerol (TG) (fractional extraction 5.7 ± 0.4%) indicated intravascular lipolysis by lipoprotein lipase, and this contributed 21 ± 3% of the glycerol released. Glucose uptake (fractional extraction 2.6 ± 0.3%) was partitioned around 20-25% for provision of glycerol 3-phosphate and 30% into lactate production. There was release of lactate and pyruvate, with extraction of the ketone bodies 3-hydroxybutyrate and acetoacetate, although these were small numerically compared with TG and glucose uptake. NEFA release (expressed per 100 g tissue) correlated inversely with measures of fat mass (e.g., with BMI, r(s) = -0.24, P < 0.001). We examined within-person variability. Systemic NEFA concentrations, NEFA release, fatty acid re-esterification, and adipose tissue blood flow were all more consistent within than between individuals. This picture of human adipose tissue metabolism in the fasted state should contribute to a greater understanding of adipose tissue physiology and pathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.