Evidence map›Paper›PMID 22167484›Full record

ReviewMolecular neurobiology2012

Post-transcriptional trafficking and regulation of neuronal gene expression.

Belinda J Goldie, Murray J Cairns

Abstract readReview
In one paragraph

Review in Molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
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  6. Article
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  8. Article
  9. Non-coding RNAs in neuropathic pain.Neuronal signaling · 2020
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  15. Article
  16. Article
  17. Article
  18. MicroRNAs in neuronal communication.Molecular neurobiology · 2014
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Belinda J GoldieSchool of Biomedical Sciences and Pharmacy, Faculty of Health and the Hunter Medical Research Institute, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.
Murray J Cairns

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular messenger RNA (mRNA) traffic and translation must be highly regulated, both temporally and spatially, within eukaryotic cells to support the complex functional partitioning. This capacity is essential in neurons because it provides a mechanism for rapid input-restricted activity-dependent protein synthesis in individual dendritic spines. While this feature is thought to be important for synaptic plasticity, the structures and mechanisms that support this capability are largely unknown. Certainly specialized RNA binding proteins and binding elements in the 3' untranslated region (UTR) of translationally regulated mRNA are important, but the subtlety and complexity of this system suggests that an intermediate "specificity" component is also involved. Small non-coding microRNA (miRNA) are essential for CNS development and may fulfill this role by acting as the guide strand for mediating complex patterns of post-transcriptional regulation. In this review we examine post-synaptic gene regulation, mRNA trafficking and the emerging role of post-transcriptional gene silencing in synaptic plasticity.

Indexed as

AnimalsGene Expression RegulationHumansNeuronsProtein TransportRNA, MessengerRNA Processing, Post-TranscriptionalRNA, Messenger

Identifiers

PMID22167484
PMCPMC3259350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.