Evidence map›Paper›PMID 22167342›Full record

ArticleJournal of autism and developmental disorders2012

Daily health symptoms of mothers of adolescents and adults with fragile x syndrome and mothers of adolescents and adults with autism spectrum disorder.

Leann E Smith, Marsha Mailick Seltzer, Jan S Greenberg

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. FMR1 genotype interacts with parenting stress to shape health and functional abilities in older age.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Trial
  3. Review
  4. Cognitive dysfunction in women with theJournal of Alzheimer's disease : JAD · 2026
    Article
  5. Article
  6. Article
  7. Depression Symptom Trajectories in Mothers With the FMR1 Premutation Vary by CGG Repeat Length: A Longitudinal Study of 73 Women Spanning 20-75 Years of Age.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Health Effects of Sleep Quality in Premutation Carrier Mothers of Individuals With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2023
    Article
  12. Improving Retention of Diverse Samples in Longitudinal Research on Developmental Disabilities.American journal on intellectual and developmental disabilities · 2023
    Article
  13. Social Network Diversity and Mental Health Among Mothers of Individuals With Autism.American journal on intellectual and developmental disabilities · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Leann E SmithWaisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI, 53705, USA. lsmith@waisman.wisc.edu
Marsha Mailick Seltzer
Jan S Greenberg
University of Wisconsin–Madison · US

Funding

STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
IMPACTS OF PARENTING ADOLESCENTS &ADULTS WITH AUTISMR01AG008768 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI MAILICK, MARSHA RUTH · 1990 to 2011
$4.3M
Daily Stress and Well-Being during AdulthoodR01AG019239 · NIA · UNIVERSITY OF ARIZONA · PI ALMEIDA, DAVID M. · 2001 to 2009
$1.2M
NIA NIH HHS P01 AG020166NIA NIH HHS R01 AG008768NIA NIH HHS R01 AG019239NIA NIH HHS R01AG019239NIA NIH HHS R01 AG08768NICHD NIH HHS P30 HD003100-S1NICHD NIH HHS P30 HD003352NICHD NIH HHS P30 HD03352
6 · The paper itself

Abstract

Health symptoms of mothers of adolescents and adults with fragile X syndrome (FXS; n = 112) were compared to a nationally-representative sample of mothers of similarly-aged children without disabilities (n = 230) as well as to a sample of mothers of adolescents and adults with autism spectrum disorders (ASD; n = 96). Health symptoms experienced in the previous 24 h were recorded during 8 consecutive days of a daily diary study. Both mothers of a son or daughter with FXS and mothers of a son or daughter with ASD had a higher proportion of days with headaches, backaches, muscle soreness, fatigue, and hot flashes than mothers of children without disabilities. Mothers of children with disabilities appear to be at particular risk for health problems, highlighting a need for comprehensive services for families across the lifespan.

Indexed as

Child Development Disorders, PervasiveFragile X SyndromeMothersAdolescentAdultAgedChildFatigueFemaleHot FlashesHumansMaleMiddle AgedMother-Child RelationsPainSurveys and Questionnaires

Identifiers

PMID22167342
PMCPMC3426638
OpenAlexW2158551509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.