ArticleArchives of virology2012
Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows.
Article in Archives of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Rodents as potential reservoirs for toroviruses.Virology journal · 2025Article
- Identification of a new goat torovirus strain: first detection and genomic analysis in China.Irish veterinary journal · 2025Article
- Genome-Wide Genomic Analysis and Evolutionary Insights into Bovine Coronavirus Strains in Southwest China.Veterinary sciences · 2024Article
- Article
- Mechanism, structural and functional insights into nidovirus-induced double-membrane vesicles.Frontiers in immunology · 2024Review
- Classification, replication, and transcription ofFrontiers in microbiology · 2023Review
- Reverse Genetics with a Full-Length Infectious cDNA Clone of Bovine Torovirus.Journal of virology · 2022Article
- Literature Review: Coinfection in Young Ruminant Livestock-Pathogens (Basel, Switzerland) · 2022Review
- Development and use of a reverse transcription insulated isothermal PCR assay for detection and characterization of bovine torovirus in yaks.Archives of virology · 2021Article
- Recent Progress in Torovirus Molecular Biology.Viruses · 2021Review
- Characterization of Localization and Export Signals of Bovine Torovirus Nucleocapsid Protein Responsible for Extensive Nuclear and Nucleolar Accumulation and Their Importance for Virus Growth.Journal of virology · 2021Article
- First report and genetic characterization of bovine torovirus in diarrhoeic calves in China.BMC veterinary research · 2020Article
- First detection and genomic characteristics of bovine torovirus in dairy calves in China.Archives of virology · 2020Article
- Molecular surveillance of viral pathogens associated with diarrhea in pre-weaned Korean native calves.Tropical animal health and production · 2020Article
- Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication.PloS one · 2019Article
- Ultrastructural characterization of membranous torovirus replication factories.Cellular microbiology · 2016Article
- Whole genome analysis of Japanese bovine toroviruses reveals natural recombination between porcine and bovine toroviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Detection and molecular characterisation of bovine corona and toroviruses from Croatian cattle.BMC veterinary research · 2015Article
- Molecular characterization and phylogenetic analysis of the genome of porcine torovirus.Archives of virology · 2014Article
- Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein.Veterinary research · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine torovirus (BToV) is recognized as an enteric pathogen of calves, but its etiological role in diarrhea and epidemiological characterization in adult cows remain unclear. In 2007-2008, three outbreaks of epidemic diarrhea occurred in adult cows at three dairy farms in Niigata Prefecture, Japan. BToV was the only enteric pathogen detected in these outbreaks, as determined by electron microscopy, reverse transcription-PCR, bacteria and parasite tests of fecal samples, and antibody tests with paired sera. The epidemiological features of the three outbreaks were similar to those of bovine coronavirus infection, except for the absence of bloody diarrhea, with diarrhea spreading among most adult cows, but not in calves, within several days and diarrhea lasting for 3-5 days with anorexia. Decreased milk production and mild respiratory symptoms were also observed in two of the outbreaks. Nucleotide sequence analysis of the BToV nucleocapsid, spike, and hemagglutinin-esterase (HE) genes revealed a close relatedness among the detected BToV strains from each outbreak and those of Japanese BToV strain Aichi/2004. Furthermore, we isolated a BToV strain, designated Niigata (TC), from a fecal sample using a human rectal tumor cell line. Sequence analysis of this isolate and Aichi/2004 indicated that both strains have truncated HE genes with deletions in the 3' region that occurred through cell culture-adaptation. The short projections that are believed to be formed by the HE protein on virus particles were not observed in these cultured strains by electron microscopy. Taken together, these results suggest that BToV causes epidemic diarrhea in adult cows and should be included in the differential diagnosis of diarrhea in adult cows. In addition, our findings indicate that the HE protein of BToV may not be necessary for viral replication.
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