ArticleNucleic acids research1990
Direct detection and automated sequencing of individual alleles after electrophoretic strand separation: identification of a common nonsense mutation in exon 9 of the human lipoprotein lipase gene.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- Meta-based association of the lipoprotein lipase gene S447X variant with hypertension and blood pressure variation.Journal of human hypertension · 2011Pooled it
- Review
- Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma.Lipids in health and disease · 2020Article
- Study of Common Genetic Variant S447X in Lipoprotein Lipase and Its Association with Lipids and Lipoproteins in Type 2 Diabetic Patients.Indian journal of clinical biochemistry : IJCB · 2016Article
- Genetic determinants of plasma triglycerides.Journal of lipid research · 2011Review
- Candidate gene association resource (CARe): design, methods, and proof of concept.Circulation. Cardiovascular genetics · 2010Article
- APOE, CETP and LPL genes show strong association with lipid levels in Greek children.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2010Article
- Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease.Atherosclerosis · 2008Article
- Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis.World journal of gastroenterology · 2006Article
- Simultaneous detection of precore/basal core promoter mutations in hepatitis B virus using arrayed primer extension.Molecular diagnosis & therapy · 2006Article
- The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia.Journal of molecular medicine (Berlin, Germany) · 2003Article
- A multilocus genotyping assay for candidate markers of cardiovascular disease risk.Genome research · 1999Article
- Common mutations of the lipoprotein lipase gene and their clinical significance.Current atherosclerosis reports · 1999Review
- Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase.American journal of human genetics · 1998Article
- Prevention of hyperlipidemic acute pancreatitis during pregnancy with medium-chain triglyceride nutritional support.International journal of pancreatology : official journal of the International Association of Pancreatology · 1998Article
- Genetic mapping of ossification of the posterior longitudinal ligament of the spine.American journal of human genetics · 1998Article
- Assessment of French patients with LPL deficiency for French Canadian mutations.Journal of medical genetics · 1997Article
- Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency.American journal of human genetics · 1996Article
- Dyslipidaemia in a boy with recurrent abdominal pain, hypersalivation and decreased lipoprotein lipase activity.European journal of pediatrics · 1996Article
- Fluorescence-based mutation detection. Single-strand conformation polymorphism analysis (F-SSCP).Molecular biotechnology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-scale screening by direct sequencing of DNA to detect molecular variants remains a laborious endeavor whose difficulty is compounded by heterozygosity. We show that mobility shifts of single-stranded DNA electrophoresed under nondenaturing conditions can be used not only to detect variants (Orita,M. et al., 1989, Genomics, 5, 874-879), but also to separate and sequence directly individual alleles. In this manner, we have identified a common variant of human lipoprotein lipase resulting from a nonsense mutation in exon 9 of the gene. Whether this variant is of functional significance remains to be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.