ArticleHeredity2012
Resistance to a bacterial parasite in the crustacean Daphnia magna shows Mendelian segregation with dominance.
Article in Heredity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- QTL study reveals candidate genes underlying host resistance in a Red Queen model system.PLoS genetics · 2023Article
- Balancing Selection for Pathogen Resistance Reveals an Intercontinental Signature of Red Queen Coevolution.Molecular biology and evolution · 2021Article
- A SNP assay for assessing diversity in immune genes in the honey bee (Apis mellifera L.).Scientific reports · 2021Article
- A Two-Locus System with Strong Epistasis Underlies Rapid Parasite-Mediated Evolution of Host Resistance.Molecular biology and evolution · 2021Article
- Rapid change in host specificity in a field population of the biological control organismEvolutionary applications · 2019Article
- The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model.PLoS genetics · 2017Article
- Sex as a strategy against rapidly evolving parasites.Proceedings. Biological sciences · 2016Article
- Host-parasite coevolution in populations of constant and variable size.BMC evolutionary biology · 2015Article
- Genetic architecture of resistance in Daphnia hosts against two species of host-specific parasites.Heredity · 2015Article
- Water fleas require microbiota for survival, growth and reproduction.The ISME journal · 2015Article
- Dietary supply with polyunsaturated fatty acids and resulting maternal effects influence host--parasite interactions.BMC ecology · 2013Article
- The expression and evolution of virulence in multiple infections: the role of specificity, relative virulence and relative dose.BMC evolutionary biology · 2013Article
- Variation in infectivity and aggressiveness in space and time in wild host-pathogen systems: causes and consequences.Journal of evolutionary biology · 2012Article
- Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of host and parasite genetic background on infection outcome is a topic of great interest because of its pertinence to theoretical issues in evolutionary biology. In the present study, we use a classical genetics approach to examine the mode of inheritance of infection outcome in the crustacean Daphnia magna when exposed to the bacterial parasite Pasteuria ramosa. In contrast to previous studies in this system, we use a clone of P. ramosa, not field isolates, which allows for a more definitive interpretation of results. We test parental, F1, F2, backcross and selfed parental clones (total 284 genotypes) for susceptibility against a clone of P. ramosa using two different methods, infection trials and the recently developed attachment test. We find that D. magna clones reliably exhibit either complete resistance or complete susceptibility to P. ramosa clone C1 and that resistance is dominant, and inherited in a pattern consistent with Mendelian segregation of a single-locus with two alleles. The finding of a single host locus controlling susceptibility to P. ramosa suggests that the previously observed genotype-genotype interactions in this system have a simple genetic basis. This has important implications for the outcome of host-parasite co-evolution. Our results add to the growing body of evidence that resistance to parasites in invertebrates is mostly coded by one or few loci with dominance.
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