ArticleHeredity2012
Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence.
Article in Heredity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Evolutionary Models for the Diversification of Placental Mammals Across the KPg Boundary.Frontiers in genetics · 2019Pooled it
- Repeated evolution and the impact of evolutionary history on adaptation.BMC evolutionary biology · 2015Pooled it
- Gene Ontology-Based Comparative Transcriptomics Provides Evidence of Genetic Adaptations in theAnimals : an open access journal from MDPI · 2026Article
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Evidence for echolocation in Asian shrew moles.National science review · 2026Article
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cochlear Cell Atlas of Two Laryngeal Echolocating Bats-New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat.Molecular ecology resources · 2025Article
- Evolutionary sparse learning reveals the shared genetic basis of convergent traits.Nature communications · 2025Article
- Single-Cell Landscape of the Cochlea Revealed Cell-Type-Specific Diversification inBiomolecules · 2025Article
- Practical Guidance and Workflows for Identifying Fast Evolving Non-Coding Genomic Elements Using PhyloAcc.Integrative and comparative biology · 2024Article
- Molecular evolution of toothed whale genes reveals adaptations to echolocating in different environments.BMC genomics · 2024Article
- Increased Positive Selection in Highly Recombining Genes Does not Necessarily Reflect an Evolutionary Advantage of Recombination.Molecular biology and evolution · 2024Article
- Accurate Detection of Convergent Mutations in Large Protein Alignments With ConDor.Genome biology and evolution · 2024Article
- Unraveling genomic features and phylogenomics through the analysis of three Mexican endemicPeerJ · 2024Article
- Convergence in hearing-related genes between echolocating birds and mammals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Repeated evolution of similar phenotypes: Integrating comparative methods with developmental pathways.Genetics and molecular biology · 2023Article
- Untargeted metabolomics of the cochleae from two laryngeally echolocating bats.Frontiers in molecular biosciences · 2023Article
- Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats.iScience · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byHearing echoes.2012
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings of sequence convergence in the Prestin gene among some bats and cetaceans suggest that parallel adaptations for high-frequency hearing have taken place during the evolution of echolocation. To determine if this gene is an exception, or instead similar processes have occurred in other hearing genes, we have examined Tmc1 and Pjvk, both of which are associated with non-syndromic hearing loss in mammals. These genes were amplified and sequenced from a number of mammalian species, including echolocating and non-echolocating bats and whales, and were analysed together with published sequences. Sections of both genes showed phylogenetic signals that conflicted with accepted species relationships, with coding regions uniting laryngeal echolocating bats in a monophyletic clade. Bayesian estimates of posterior probabilities of convergent and divergent substitutions provided more direct evidence of sequence convergence between the two groups of laryngeal echolocating bats as well as between echolocating bats and dolphins. We found strong evidence of positive selection acting on some echolocating bat species and echolocating cetaceans, contrasting with purifying selection on non-echolocating bats. Signatures of sequence convergence and molecular adaptation in two additional hearing genes suggest that the acquisition of high-frequency hearing has involved multiple loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.