ArticleLab on a chip2012
Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration.Theranostics · 2025Review
- Gradient scaffolds in bone-soft tissue interface engineering: Structural characteristics, fabrication techniques, and emerging trends.Journal of orthopaedic translation · 2025Review
- Gradient Hydrogels.Advances in biochemical engineering/biotechnology · 2021Article
- Gradient nanocomposite hydrogels for interface tissue engineering.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Generation of micro-droplet arrays by dip-coating of biphilic surfaces; the dependence of entrained droplet volume on withdrawal velocity.Scientific reports · 2017Article
- Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.Biomaterials · 2015Review
- A Current View of Functional Biomaterials for Wound Care, Molecular and Cellular Therapies.BioMed research international · 2015Review
- Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment.Lab on a chip · 2014Article
- 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.Advanced materials (Deerfield Beach, Fla.) · 2014Review
- Biochemical and physical signal gradients in hydrogels to control stem cell behavior.Advanced materials (Deerfield Beach, Fla.) · 2013Article
- A microfluidic system to study the cytotoxic effect of drugs: the combined effect of celecoxib and 5-fluorouracil on normal and cancer cells.Mikrochimica acta · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This technical note describes a new bench-top method for producing anisotropic hydrogels composed of gradient layers of soluble factors, particles, polymer concentrations or material properties. Each gradient layer was produced by a previous gradient method in which a droplet of one precursor solution was added to a thin layer of a second solution. The ensuing rapid capillary flow along the open channel generated a gradient precursor solution, which was then crosslinked to form a gradient gel. Repeating these steps allowed a layered gel to be iteratively constructed with as many gradient layers as desired. This technique renders the synthesis of multi-layered gradient gels accessible to virtually any researcher and should help simplify the production of more biologically relevant cellular microenvironments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.