Trial reportCritical care (London, England)2011
Long-term psychological effects of a no-sedation protocol in critically ill patients.
Trial report in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02040649 (Substudy of the NONSEDA-trial), which is not on this map. Cited by 30 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Substudy of the NONSEDA-trial (NCT01967680): Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Me-chanical Ventilation - Effects on Posttraumatic Stress Disorder
Who cites it
30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis.Critical care (London, England) · 2019Pooled it
- Interventions for preventing intensive care unit delirium in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit.The Cochrane database of systematic reviews · 2018Pooled it
- Depressive Symptoms After Critical Illness: A Systematic Review and Meta-Analysis.Critical care medicine · 2016Pooled it
- Pooled it
- Anxiety symptoms in survivors of critical illness: a systematic review and meta-analysis.General hospital psychiatryPooled it
- Trial
- The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury.American journal of respiratory and critical care medicine · 2012Trial
- Glymphatic dysfunction: a unifying hypothesis for delirium.Nature reviews. Neurology · 2026Review
- Pain Assessment with the BPS and CCPOT Behavioral Pain Scales in Mechanically Ventilated Patients Requiring Analgesia and Sedation.International journal of environmental research and public health · 2022Article
- Clinical Practice: Should we Radically Alter our Sedation of Critical Care Patients, Especially Given the COVID-19 Pandemics?Romanian journal of anaesthesia and intensive care · 2020Article
- The effects of sedation cessation within the first four hours of intensive care unit admission in mechanically ventilated critically ill patients - a quality improvement study.EClinicalMedicine · 2020Article
- Post traumatic stress symptoms, anxiety, and depression in patients after intensive care unit discharge - a longitudinal cohort study from a LMIC tertiary care centre.BMC psychiatry · 2020Article
- Evolving targets for sedation during mechanical ventilation.Current opinion in critical care · 2020Review
- "Sedation is tricky": A qualitative content analysis of nurses' perceptions of sedation administration in mechanically ventilated intensive care unit patients.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2018Article
- Early psychological screening of intensive care unit survivors: a prospective cohort study.Critical care (London, England) · 2017Observational
- The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- [Depressive, anxiety and posttraumatic stress disorders as long-term sequelae of intensive care treatment].Der Nervenarzt · 2016Review
- Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA protocol of no sedation has been shown to reduce the time patients receive mechanical ventilation and to reduce intensive care and total hospital length of stay. The long-term psychological effects of this strategy have not yet been described. The purpose of the study was to test whether a strategy of no sedation alters long-term psychological outcome compared with a standard strategy with sedation.
methodsDuring intensive care stay, 140 patients requiring mechanical ventilation were randomized to either no sedation or sedation with daily interruption of sedation. This study was done as a single-blinded cohort study. After discharge, patients were interviewed by a neuropsychologist assessing quality of life, depression, anxiety, and posttraumatic stress disorder.
resultsTwo years after randomization, 38 patients were eligible for interview, and 26 patients were interviewed (13 from each group). No difference was found with respect to quality of life (Medical Outcome Study, 36-item short-form health survey). Both mental and physical components were nonsignificant. The Beck depression index was low in both groups (one patient in intervention group versus three patients in the control group were depressed, p = 0.32). Evaluated with the Impact of Events Scale, both groups had low stress scores (one in the intervention group versus two in the control group had scores greater than 32; p = 0.50). State anxiety scores were also low (28 in the control group versus 30 in the intervention group, p = 0.58).
conclusionsOur data suggest that a protocol of no sedation applied to critically ill patients undergoing mechanical ventilation does not increase the risk of long-term psychological sequelae after intensive care compared with standard treatment with sedation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.