ReviewParkinsonism & related disorders2012
Neurorestoration.
Review in Parkinsonism & related disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Article
- The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease.Translational neurodegeneration · 2020Review
- Neuroprotective and Neurorestorative Effects ofFrontiers in neuroscience · 2020Article
- Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson's Disease.Journal of Parkinson's disease · 2019Article
- Identification of biomarkers associated with Parkinson's disease by gene expression profiling studies and bioinformatics analysis.AIMS neuroscience · 2019Review
- α‑synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum‑Golgi compartment.Molecular medicine reports · 2018Article
- Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease.Frontiers in neurology · 2018Review
- Association Between Serum Vitamin D Levels and Parkinson's Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2018Article
- Article
- Update of neurotrophic factors in neurobiology of addiction and future directions.Neurobiology of disease · 2017Review
- IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases.Experimental brain research · 2016Article
- Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice.International journal of molecular sciences · 2016Review
- Bile Acids in Neurodegenerative Disorders.Frontiers in aging neuroscience · 2016Review
- Physical Fitness and Serum Vitamin D and Cognition in Elderly Koreans.Journal of sports science & medicine · 2015Article
- The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system.Neural regeneration research · 2015Article
- Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review.Life sciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to have neuroprotective and neuroregenerative activity in the adult central nervous system, particularly for midbrain dopamine neurons (MDN). Neurorestoration is potentially feasible for MDN since there is an initial loss of phenotype for these neurons in Parkinson's disease (PD) rather than neuronal death. There is a considerable recent literature on trophic properties of TGF-β superfamily proteins for MDN's, including glial cell-derived neurotrophic factor (GDNF), neurturin, and bone morphogenetic proteins (BMPs). This paper will review studies with the factors listed above, as well as describe more recent studies with two newly described trophic proteins, MANF and CDNF. Data will be presented from various animal models of PD suggesting that these trophic proteins may eventually lead to PD therapeutics in man. In addition, some data on small molecules with neuroprotective properties (AP(4)A, retinoic acid and vitamin D(3)) will also be described.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.