ArticleMolecular neurodegeneration2011
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons.
Article in Molecular neurodegeneration, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Potential Regulation of the Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript1 by Estrogen in Parkinson's Disease.Life (Basel, Switzerland) · 2024Review
- α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice.NPJ Parkinson's disease · 2024Article
- Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson's disease.Experimental & molecular medicine · 2023Article
- Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Article
- A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease.Molecular neurobiology · 2021Article
- Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.Frontiers in neuroscience · 2020Article
- Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson's Disease.Molecular therapy. Nucleic acids · 2017Article
- Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.BMC neuroscience · 2017Article
- SNCA Gene Polymorphism may Contribute to an Increased Risk of Alzheimer's Disease.Journal of clinical laboratory analysis · 2016Article
- Exogenous α-Synuclein Monomers Alter Dopamine Metabolism in Murine Brain.Neurochemical research · 2016Article
- Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.Human molecular genetics · 2016Article
- Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications.PloS one · 2016Article
- Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.Cellular and molecular life sciences : CMLS · 2015Review
- Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Neurobiology of disease · 2014Article
- AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.Synapse (New York, N.Y.) · 2013Article
- Striatal molecular signature of subchronic subthalamic nucleus high frequency stimulation in parkinsonian rat.PloS one · 2013Article
- Gene expression profiling in human neurodegenerative disease.Nature reviews. Neurology · 2012Review
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other synucleinopathies. Furthermore, SNCA is ubiquitously expressed in neurons and numerous neuronal systems are dysfunctional in PD. Therefore it is of interest to understand how overexpression of SNCA affects neuronal function in regions not directly targeted for neurodegeneration in PD.
resultsThe present study investigated the consequences of SNCA overexpression on cellular processes and functions in the striatum of mice overexpressing wild-type, human SNCA under the Thy1 promoter (Thy1-aSyn mice) by transcriptome analysis. The analysis revealed alterations in multiple biological processes in the striatum of Thy1-aSyn mice, including synaptic plasticity, signaling, transcription, apoptosis, and neurogenesis.
conclusionThe results support a key role for SNCA in synaptic function and revealed an apoptotic signature in Thy1-aSyn mice, which together with specific alterations of neuroprotective genes suggest the activation of adaptive compensatory mechanisms that may protect striatal neurons in conditions of neuronal overexpression of SNCA.
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