ArticleACS nano2012
Stacked graphene-Al2O3 nanopore sensors for sensitive detection of DNA and DNA-protein complexes.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Spontaneous Intercalation of Graphene on Sapphire.Small methods · 2026Article
- Controllable Fabrication of Sub-10 nm Graphene Nanopores via Helium Ion Microscopy and DNA Detection.Biosensors · 2024Article
- Fast Fabrication Nanopores on a PMMA Membrane by a Local High Electric Field Controlled Breakdown.Sensors (Basel, Switzerland) · 2024Article
- Interplay of graphene-DNA interactions: Unveiling sensing potential of graphene materials.Applied physics reviews · 2024Article
- Scaling of ionic conductance in a fluctuating single-layer nanoporous membrane.Scientific reports · 2023Article
- Aprotic Solvent Accumulation Amplifies Ion Current Rectification in Conical Nanopores.The journal of physical chemistry. B · 2022Article
- Electric control of ionic transport in sub-nm nanopores.RSC advances · 2021Article
- Slowing down DNA translocation through solid-state nanopores by edge-field leakage.Nature communications · 2021Article
- Single-Entity Detection With TEM-Fabricated Nanopores.Frontiers in chemistry · 2021Review
- Graphene, an Interesting Nanocarbon Allotrope for Biosensing Applications: Advances, Insights, and Prospects.Biomedical engineering and computational biology · 2021Review
- Resistive amplitude fingerprints during translocation of linear molecules through charged solid-state nanopores.The Journal of chemical physics · 2020Article
- Atomic mechanism of strong interactions at the graphene/sapphire interface.Nature communications · 2019Article
- Wireless nanopore electrodes for analysis of single entities.Nature protocols · 2019Article
- Fabrication and Applications of Solid-State Nanopores.Sensors (Basel, Switzerland) · 2019Review
- Colloquium: Ionic phenomena in nanoscale pores through 2D materials.Reviews of modern physics · 2019Article
- Scalable fabrication of sub-10 nm polymer nanopores for DNA analysis.Microsystems & nanoengineering · 2019Article
- The dynamics of electron beam scattering on metal membranes: nanopore formation in metal membranes using transmission electron microscopy.Nano convergence · 2018Article
- Noise Analysis of Monolayer Graphene Nanopores.International journal of molecular sciences · 2018Article
- The Utility of Nanopore Technology for Protein and Peptide Sensing.Proteomics · 2018Review
- Ultra-low Impedance Graphene Microelectrodes with High Optical Transparency for Simultaneous Deep 2-photon Imaging in Transgenic Mice.Advanced functional materials · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We report the development of a multilayered graphene-Al(2)O(3) nanopore platform for the sensitive detection of DNA and DNA-protein complexes. Graphene-Al(2)O(3) nanolaminate membranes are formed by sequentially depositing layers of graphene and Al(2)O(3), with nanopores being formed in these membranes using an electron-beam sculpting process. The resulting nanopores are highly robust, exhibit low electrical noise (significantly lower than nanopores in pure graphene), are highly sensitive to electrolyte pH at low KCl concentrations (attributed to the high buffer capacity of Al(2)O(3)), and permit the electrical biasing of the embedded graphene electrode, thereby allowing for three terminal nanopore measurements. In proof-of-principle biomolecule sensing experiments, the folded and unfolded transport of single DNA molecules and RecA-coated DNA complexes could be discerned with high temporal resolution. The process described here also enables nanopore integration with new graphene-based structures, including nanoribbons and nanogaps, for single-molecule DNA sequencing and medical diagnostic applications.
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Registered trials
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