ArticleInternational journal of evolutionary biology2011
Functional diversification of fungal glutathione transferases from the ure2p class.
Article in International journal of evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Advances in the Degradation of Polycyclic Aromatic Hydrocarbons by Yeasts: A Review.Microorganisms · 2024Review
- Genome-Scale Screening ofJournal of fungi (Basel, Switzerland) · 2024Article
- Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.Advances in cancer research · 2024Review
- Characterization of the GlutathioneMicrobiology spectrum · 2021Article
- Wheat pathogenRSC chemical biology · 2020Article
- Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin.The Journal of biological chemistry · 2016Article
- Characterization of glutathione transferases involved in the pathogenicity of Alternaria brassicicola.BMC microbiology · 2015Article
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- Article
- Xenomic networks variability and adaptation traits in wood decaying fungi.Microbial biotechnology · 2013Review
- Diversification of fungal specific class a glutathione transferases in saprotrophic fungi.PloS one · 2013Article
- Characterization of a Phanerochaete chrysosporium glutathione transferase reveals a novel structural and functional class with ligandin properties.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glutathione-S-transferase (GST) proteins represent an extended family involved in detoxification processes. They are divided into various classes with high diversity in various organisms. The Ure2p class is especially expanded in saprophytic fungi compared to other fungi. This class is subdivided into two subclasses named Ure2pA and Ure2pB, which have rapidly diversified among fungal phyla. We have focused our analysis on Basidiomycetes and used Phanerochaete chrysosporium as a model to correlate the sequence diversity with the functional diversity of these glutathione transferases. The results show that among the nine isoforms found in P. chrysosporium, two belonging to Ure2pA subclass are exclusively expressed at the transcriptional level in presence of polycyclic aromatic compounds. Moreover, we have highlighted differential catalytic activities and substrate specificities between Ure2pA and Ure2pB isoforms. This diversity of sequence and function suggests that fungal Ure2p sequences have evolved rapidly in response to environmental constraints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.