ArticlePloS one2011
Bioinformatic analysis and post-translational modification crosstalk prediction of lysine acetylation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Precision Chemistry for Protein Lysine Modification.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Insight into the roles of lactylation in macrophages: functions and clinical implications.Clinical science (London, England : 1979) · 2025Review
- Posttranslational Modifications ofPharmacological reviews · 2024Review
- Article
- Acetylproteomics analyses reveal critical features of lysine-ε-acetylation in Arabidopsis and a role of 14-3-3 protein acetylation in alkaline response.Stress biology · 2022Article
- Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma.Clinical and translational medicine · 2021Article
- A Molecular Perspective on Sirtuin Activity.International journal of molecular sciences · 2020Review
- PTM-ssMP: A Web Server for Predicting Different Types of Post-translational Modification Sites Using Novel Site-specific Modification Profile.International journal of biological sciences · 2018Article
- Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.FEBS letters · 2017Article
- Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells.Cell cycle (Georgetown, Tex.) · 2017Article
- Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes.Molecular & cellular proteomics : MCP · 2016Article
- Position-specific prediction of methylation sites from sequence conservation based on information theory.Scientific reports · 2015Article
- Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases.Scientific reports · 2015Article
- A Comparative Analysis and Review of lysyl Residues Affected by Posttranslational Modifications.Current genomics · 2015Article
- Systematic characterization and prediction of post-translational modification cross-talk.Molecular & cellular proteomics : MCP · 2015Article
- Systematic analysis of the in situ crosstalk of tyrosine modifications reveals no additional natural selection on multiply modified residues.Scientific reports · 2014Article
- Discriminating between lysine sumoylation and lysine acetylation using mRMR feature selection and analysis.PloS one · 2014Article
- In silico analysis of protein Lys-N(𝜀)-acetylation in plants.Frontiers in plant science · 2014Review
- Initial characterization of histone H3 serine 10 O-acetylation.Epigenetics · 2013Article
- Post-translational modification of proteins in toxicological research: focus on lysine acylation.Toxicological research · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent proteomics studies suggest high abundance and a much wider role for lysine acetylation (K-Ac) in cellular functions. Nevertheless, cross influence between K-Ac and other post-translational modifications (PTMs) has not been carefully examined. Here, we used a variety of bioinformatics tools to analyze several available K-Ac datasets. Using gene ontology databases, we demonstrate that K-Ac sites are found in all cellular compartments. KEGG analysis indicates that the K-Ac sites are found on proteins responsible for a diverse and wide array of vital cellular functions. Domain structure prediction shows that K-Ac sites are found throughout a wide variety of protein domains, including those in heat shock proteins and those involved in cell cycle functions and DNA repair. Secondary structure prediction proves that K-Ac sites are preferentially found in ordered structures such as alpha helices and beta sheets. Finally, by mutating K-Ac sites in silico and predicting the effect on nearby phosphorylation sites, we demonstrate that the majority of lysine acetylation sites have the potential to impact protein phosphorylation, methylation, and ubiquitination status. Our work validates earlier smaller-scale studies on the acetylome and demonstrates the importance of PTM crosstalk for regulation of cellular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.