ArticleToxicological and environmental chemistry2011
The plausibility of a role for mercury in the etiology of autism: a cellular perspective.
Article in Toxicological and environmental chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Evaluation of the divergent effects of pyrethroid- and D-allethrin-based coil fumes in male Wistar rats.Environmental analysis, health and toxicology · 2025Article
- The Impact of Mercury from Dental Amalgams on Pregnancy and Childhood: A Health and Risk Assessment Evaluation.Current medicinal chemistry · 2025Review
- Identification of potentially relevant metals for the etiology of autism by using a Bayesian multivariate approach for partially censored values.Scientific reports · 2023Article
- Interactive associations of eczema with glutathione S-transferase genes in relation to autism spectrum disorder and its severity in Jamaican children.Research in autism spectrum disorders · 2023Article
- Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.International journal of environmental research and public health · 2022Article
- Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in Zebrafish.International journal of molecular sciences · 2021Article
- Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children.Journal of autism and developmental disorders · 2021Article
- Associations of Metabolic Genes (International journal of environmental research and public health · 2021Article
- Correlation between concentrations of four heavy metals in cord blood and childhood blood of Jamaican children.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering · 2021Article
- Aberrant Mitochondrial Morphology and Function in the BTBR Mouse Model of Autism Is Improved by Two Weeks of Ketogenic Diet.International journal of molecular sciences · 2020Article
- Association Study Between Metallothionein-3 Protein Polymorphisms and Autism.Neurotoxicity research · 2018Article
- Neurodevelopmental Effects of Mercury.Advances in neurotoxicology · 2018Article
- A Two-Phase Case-Control Study of Autism Risk Among Children Born From the Late 1990s Through the Early 2000s in the United States.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Chelation for autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2015Article
- Interaction betweenResearch in autism spectrum disorders · 2015Article
- Autism-Like Behavior and Epigenetic Changes Associated with Autism as Consequences of In Utero Exposure to Environmental Pollutants in a Mouse Model.Behavioural neurology · 2015Article
- A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors.Environmental health : a global access science source · 2014Article
- Impairment of translation in neurons as a putative causative factor for autism.Biology direct · 2014Article
- A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders.Behavioral and brain functions : BBF · 2014Article
- Hair toxic metal concentrations and autism spectrum disorder severity in young children.International journal of environmental research and public health · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is defined by a behavioral set of stereotypic and repetitious behavioral patterns in combination with social and communication deficits. There is emerging evidence supporting the hypothesis that autism may result from a combination of genetic susceptibility and exposure to environmental toxins at critical moments in development. Mercury (Hg) is recognized as a ubiquitous environmental neurotoxin and there is mounting evidence linking it to neurodevelopmental disorders, including autism. Of course, the evidence is not derived from experimental trials with humans but rather from methods focusing on biomarkers of Hg damage, measurements of Hg exposure, epidemiological data, and animal studies. For ethical reasons, controlled Hg exposure in humans will never be conducted. Therefore, to properly evaluate the Hg-autism etiological hypothesis, it is essential to first establish the biological plausibility of the hypothesis. This review examines the plausibility of Hg as the primary etiological agent driving the cellular mechanisms by which Hg-induced neurotoxicity may result in the physiological attributes of autism. Key areas of focus include: (1) route and cellular mechanisms of Hg exposure in autism; (2) current research and examples of possible genetic variables that are linked to both Hg sensitivity and autism; (3) the role Hg may play as an environmental toxin fueling the oxidative stress found in autism; (4) role of mitochondrial dysfunction; and (5) possible role of Hg in abnormal neuroexcitory and excitotoxity that may play a role in the immune dysregulation found in autism. Future research directions that would assist in addressing the gaps in our knowledge are proposed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.