ArticleDementia and geriatric cognitive disorders extra2011
The efficacy of licensed-indication use of donepezil and memantine monotherapies for treating behavioural and psychological symptoms of dementia in patients with Alzheimer's disease: systematic review and meta-analysis.
Article in Dementia and geriatric cognitive disorders extra, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- [Therapy strategies for repetitive vocalizations in dementia : A systematic review].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2025Pooled it
- Alzheimer's Disease: Efficacy of Mono- and Combination Therapy. A Systematic Review.Journal of geriatric psychiatry and neurology · 2022Pooled it
- Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis.PloS one · 2017Pooled it
- The comparative efficacy and safety of cholinesterase inhibitors in patients with mild-to-moderate Alzheimer's disease: a Bayesian network meta-analysis.International journal of geriatric psychiatry · 2016Pooled it
- Efficacy and adverse effects of memantine treatment for Alzheimer's disease from randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Pooled it
- Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews.Biomedicines · 2021Review
- Efficacy of serious exergames in improving neuropsychiatric symptoms in neurocognitive disorders: Results of the X-TORP cluster randomized trial.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Effects of a multifaceted intervention in psychogeriatric patients: one-year prospective study.European journal of hospital pharmacy : science and practice · 2020Article
- The Hyperactivity-Impulsivity-Irritiability-Disinhibition-Aggression-Agitation Domain in Alzheimer's Disease: Current Management and Future Directions.Frontiers in pharmacology · 2019Review
- Dementia-related agitation: a review of non-pharmacological interventions and analysis of risks and benefits of pharmacotherapy.Translational psychiatry · 2017Review
- Management of Depression in Patients with Dementia: Is Pharmacological Treatment Justified?Drugs & aging · 2017Review
- Brain tissue modifications induced by cholinergic therapy in Alzheimer's disease.Human brain mapping · 2013Article
- Impact of Plasma Donepezil Concentration on Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease.Dementia and geriatric cognitive disorders extraArticle
- Demographic and neuropsychiatric factors associated with off-label medication use in frontotemporal dementia and Alzheimer's disease.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsBehavioural and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) greatly increase caregiver burden. The abilities of donepezil and memantine to manage BPSD within their licensed indications in AD were compared.
methodsA systematic review, random effects meta-analysis and Bucher indirect comparison were conducted.
resultsSix randomised controlled studies (4 donepezil and 2 memantine) reported use within the licensed indication and had Neuropsychiatric Inventory (NPI) data suitable for meta-analysis. BPSD showed significant improvement with donepezil compared with placebo [weighted mean difference (WMD) in NPI -3.51, 95% confidence interval (CI) -5.75, -1.27], whereas this was not the case for memantine (WMD -1.65, 95% CI -4.78, 1.49). WMD in NPI for donepezil versus memantine favoured donepezil but was not statistically significant (-1.86, 95% CI -5.71, 1.99; p = 0.34).
conclusionWithin its licensed indication, donepezil is efficacious for the management of BPSD in AD compared with placebo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.