ArticleDementia and geriatric cognitive disorders extra2011
Midlife healthy-diet index and late-life dementia and Alzheimer's disease.
Article in Dementia and geriatric cognitive disorders extra, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- A critical review and classification of dementia risk assessment tools to inform dementia risk reduction.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Dietary pattern in relation to the risk of Alzheimer's disease: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Dietary Patterns and Risk of Dementia: a Systematic Review and Meta-Analysis of Cohort Studies.Molecular neurobiology · 2016Pooled it
- Article
- The influence of healthy eating index on cognitive function in older adults: chain mediation by psychological balance and depressive symptoms.BMC geriatrics · 2024Article
- Article
- How to prevent non-communicable diseases? - A continuous need for a better understanding of the role of nutritional factors through scientific research.European journal of clinical nutrition · 2022Review
- Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice.International journal of molecular sciences · 2022Article
- Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells.Cells · 2021Review
- Methamphetamine Blocks Adenosine AInternational journal of molecular sciences · 2021Article
- Adherence to Healthy Diet Can Delay Alzheimer's Diseases Development: A Systematic Review and Meta-Analysis.Preventive nutrition and food science · 2020Review
- Dietary fatty acids and risk of Alzheimer's disease and related dementias: Observations from the Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Observational
- Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland.PLoS medicine · 2020Article
- Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors.Molecules (Basel, Switzerland) · 2020Review
- Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.International journal of geriatric psychiatry · 2020Article
- The 4 D's of Pellagra and Progress.International journal of tryptophan research : IJTR · 2020Review
- Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson's Disease.Frontiers in aging neuroscience · 2020Article
- Dietary patterns during adulthood and cognitive performance in midlife: The CARDIA study.Neurology · 2019Article
- Effects of exercise and nutrition education programs on motor function and eating habit in mild dementia patients.Journal of exercise rehabilitation · 2019Article
- Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD).
methodsOf 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components.
resultsPersons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders.
conclusionsHealthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.