SynthesisInternational journal of environmental research and public health2011
Trichloroethylene and cancer: systematic and quantitative review of epidemiologic evidence for identifying hazards.
Synthesis in International journal of environmental research and public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Occupational exposure to asbestos and risk of kidney cancer: an updated meta-analysis.European journal of epidemiology · 2021Pooled it
- Elucidating the Mechanisms of Trichloroethylene-Induced Kidney Cancer: Network Toxicology, Molecular Docking, and In Vitro Validation.Journal of biochemical and molecular toxicology · 2026Article
- Environmental risk factors for liver cancer.Hepatology (Baltimore, Md.) · 2025Article
- Cancer Incidence among Marines and Navy Personnel and Civilian Workers Exposed to Industrial Solvents in Drinking Water at US Marine Corps Base Camp Lejeune: A Cohort Study.Environmental health perspectives · 2024Article
- Evaluation of mortality among Marines, Navy personnel, and civilian workers exposed to contaminated drinking water at USMC base Camp Lejeune: a cohort study.Environmental health : a global access science source · 2024Article
- Current advances of chlorinated organics degradation by bioelectrochemical systems: a review.World journal of microbiology & biotechnology · 2024Review
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis.Chemical research in toxicology · 2023Review
- Current status of development of methylation biomarkers for in vitro diagnostic IVD applications.Clinical epigenetics · 2020Review
- Placenta as a target of trichloroethylene toxicity.Environmental science. Processes & impacts · 2020Article
- Preparation of Carbotrap/silica composite for needle trap field sampling of halogenated volatile organic compounds followed by gas chromatography/mass spectrometry determination.Journal of environmental health science & engineering · 2019Article
- In Reply.Deutsches Arzteblatt international · 2017Article
- Occupational exposure to chlorinated solvents and kidney cancer: a case-control study.Occupational and environmental medicine · 2017Article
- Mortality in a combined cohort of uranium enrichment workers.American journal of industrial medicine · 2017Article
- High-resolution metabolomics of occupational exposure to trichloroethylene.International journal of epidemiology · 2016Article
- Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers.Occupational and environmental medicine · 2016Article
- Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.The Journal of pharmacology and experimental therapeutics · 2016Review
- Residential cancer cluster investigation nearby a Superfund Study Area with trichloroethylene contamination.Cancer causes & control : CCC · 2016Article
- Increased cytogenetic abnormalities in exfoliated oral mucosal cells of South Indian foundry workers.Environmental science and pollution research international · 2015Article
- Case report of renal cell carcinoma in automobile manufacturing factory worker due to trichloroethylene exposure in Korea.Annals of occupational and environmental medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design features, exposure assessment approaches, statistical analyses, and potential sources of confounding and bias identified twenty-four cohort and case-control studies on TCE and the three cancers of interest with high potential for exposure, including five recently published case-control studies of kidney cancer or NHL. Fixed- and random-effects models were fitted to the data on overall exposure and on the highest exposure group. Sensitivity analyses examined the influence of individual studies and of alternative risk estimate selections. For overall TCE exposure and kidney cancer, the summary relative risk (RRm) estimate from the random effects model was 1.27 (95% CI: 1.13, 1.43), with a higher RRm for the highest exposure groups (1.58, 95% CI: 1.28, 1.96). The RRm estimates were not overly sensitive to alternative risk estimate selections or to removal of an individual study. There was no apparent heterogeneity or publication bias. For NHL, RRm estimates for overall exposure and for the highest exposure group, respectively, were 1.23 (95% CI: 1.07, 1.42) and 1.43 (95% CI: 1.13, 1.82) and, for liver cancer, 1.29 (95% CI: 1.07, 1.56) and 1.28 (95% CI: 0.93, 1.77). Our findings provide strong support for a causal association between TCE exposure and kidney cancer. The support is strong but less robust for NHL, where issues of study heterogeneity, potential publication bias, and weaker exposure-response results contribute uncertainty, and more limited for liver cancer, where only cohort studies with small numbers of cases were available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.