ArticleBasal ganglia2011
The mesopontine rostromedial tegmental nucleus: an integrative modulator of the reward system.
Article in Basal ganglia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA.Neuropharmacology · 2024Article
- The rostromedial tegmental (RMTg) "brake" on dopamine and behavior: A decade of progress but also much unfinished work.Neuropharmacology · 2021Review
- Neural Substrates and Circuits of Drug Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Activation of peroxisome proliferator-activated receptor γ reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem.Translational psychiatry · 2020Article
- Article
- Nicotine Increases Spontaneous Glutamate Release in the Rostromedial Tegmental Nucleus.Frontiers in neuroscience · 2020Article
- Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.Brain structure & function · 2019Article
- Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons.Neuroscience and biobehavioral reviews · 2017Review
- Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving.Pharmacology, biochemistry, and behavior · 2017Review
- Learning From One's Mistakes: A Dual Role for the Rostromedial Tegmental Nucleus in the Encoding and Expression of Punished Reward Seeking.Biological psychiatry · 2017Article
- Asymmetry in functional connectivity of the human habenula revealed by high-resolution cardiac-gated resting state imaging.Human brain mapping · 2016Article
- Multiplexed neurochemical signaling by neurons of the ventral tegmental area.Journal of chemical neuroanatomy · 2016Review
- Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat.The Journal of comparative neurology · 2015Article
- Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Regulation of dopamine system responsivity and its adaptive and pathological response to stress.Proceedings. Biological sciences · 2015Review
- Modulation of locomotor activation by the rostromedial tegmental nucleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Review
- Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum.Brain structure & function · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mesopontine rostromedial tegmental nucleus (RMTg) is a newly discovered brain structure thought to profoundly influence reward-related pathways. The RMTg is prominently GABAergic, receives dense projections from the lateral habenula and projects strongly to the midbrain ventral tegmental area and substantia nigra compacta. It receives additional afferent connections from widespread brain structures and sends additional strong efferent connections to a number of non-dopaminergic brainstem structures and, to a lesser extent, the forebrain. Projection neurons of the RMTg have been shown to express Fos in response to aversive stimuli and/or reward omission and psychostimulant drug administration. This review will first recount how the RMTg was discovered and then describe in greater detail what is known about its neuroanatomical relationships, including afferent and efferent connections, neurotransmitters, and receptors. Finally, we will focus on what has been reported about its function.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.