Evidence map›Paper›PMID 22163081›Full record

ArticleJournal of interventional gastroenterology2011

Removal of infused water predominantly during insertion (water exchange) is consistently associated with a greater reduction of pain score - review of randomized controlled trials (RCTs) of water method colonoscopy.

Fw Leung, Jo Harker, Jw Leung, Rm Siao-Salera, Sk Mann, Fc Ramirez, S Friedland, A Amato, F Radaelli, S Paggi and 2 more

5 registry-linked trialsAbstract read
In one paragraph

Article in Journal of interventional gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01535326 nacompletednot on this mapstarted 2012, after this paper: background citation

Comparing Air Insufflation, Water Immersion and Water Exchange Methods During Minimal Sedated Colonoscopy, a Randomized, Controlled Trial

TypeinterventionalSponsorDalin Tzu Chi General HospitalRan2012 to 2013Enrolled270ConditionsColon Neoplasm, PainArmsair insufflation, water immersion, water exchange
NCT01607255 phase4completednot on this mapstarted 2013, after this paper: background citation

Comparative Efficacy of Water & Indigo Carmine vs Water or Air Method

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2013 to 2017Enrolled480ConditionsColorectal NeoplasmsArmsIndigo carmine, water (exchange) method, water (exchange) plus dye method, air method
NCT01633333 nacompletednot on this mapstarted 2012, after this paper: background citation

Water Exchange Versus Carbon Dioxide Insufflation to Improve Colonoscopy Screening - a Randomized Controlled Trial

TypeinterventionalSponsorSorlandet Hospital HFRan2012 to 2013Enrolled473ConditionsColorectal Cancer, Colorectal Adenomas, Colorectal Polyps, PainArmsWater exchange colonoscopy, Carbon dioxide insufflation
NCT01780818 nacompletednot on this mapstarted 2013, after this paper: background citation

A Randomized, Controlled Trial Comparing Air Insufflation, Water Immersion and Water Exchange During on Demand Sedation Colonoscopy in CRC Screening Patients

TypeinterventionalSponsorPresidio Ospedaliero Santa BarbaraRan2013 to 2013Enrolled288ConditionsPain, Colorectal Adenomas, Colorectal CancerArmsAir Insufflation method., Water Immersion method., Water Exchange method.
NCT01781650 nacompletednot on this mapstarted 2013, after this paper: background citation

A Randomized, Controlled Trial Comparing Air Insufflation, Water Immersion and Water Exchange During on Demand Sedation Colonoscopy in Diagnostic Patients

TypeinterventionalSponsorPresidio Ospedaliero Santa BarbaraRan2013 to 2013Enrolled288ConditionsPain, Colorectal Adenomas, Colorectal CancerArmsAir Insufflation method., Water Immersion method., Water Exchange method.
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Is water exchange superior to water immersion for colonoscopy? A systematic review and meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Article
  8. The water exchange method and difficult colonoscopy.Journal of interventional gastroenterology · 2012
    Article
  9. The water exchange method for colonoscopy-effect of coaching.Journal of interventional gastroenterology · 2012
    Article
  10. Can old dogs learn new tricks?Journal of interventional gastroenterology · 2012
    Article
  11. Article
  12. Colonoscopy: Reducing faecal incontinence following colonoscopy.Nature reviews. Gastroenterology & hepatology · 2012
    Article
  13. Unsedated colonoscopy: A neverending story.World journal of gastrointestinal endoscopy · 2012
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Fw LeungSepulveda ACC, VAGLAHS, North Hill, CA; USA.
Jo Harker
Jw Leung
Rm Siao-Salera
Sk Mann
Fc Ramirez
S Friedland
A Amato
F Radaelli
S Paggi
V Terruzzi
Yh Hsieh
VA Sepulveda Ambulatory Care Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVariation in the outcomes in RcTs comparing water-related methods and air insufflation during the insertion phase of colonoscopy raises challenging questions regarding the approach. This report reviews the impact of water exchange on the variation in attenuation of pain during colonoscopy by water-related methods.

methodsMedline (2008 to 2011) searches, abstracts of the 2011 Digestive Disease Week (DDW) and personal communications were considered to identify RcTs that compared water-related methods and air insufflation to aid insertion of the colonoscope. Results: Since 2008 nine published and one submitted RcTs and five abstracts of RcTs presented at the 2011 DDW have been identified. Thirteen RcTs (nine published, one submitted and one abstract, n=1850) described reduction of pain score during or after colonoscopy (eleven reported statistical significance); the remaining reports described lower doses of medication used, or lower proportion of patients experiencing severe pain in colonoscopy performed with water-related methods compared with air insufflation (Tables 1 and 2). The water-related methods notably differ in the timing of removal of the infused water - predominantly during insertion (water exchange) versus predominantly during withdrawal (water immersion). Use of water exchange was consistently associated with a greater attenuation of pain score in patients who did not receive full sedation (Table 3).

conclusionThe comparative data reveal that a greater attenuation of pain was associated with water exchange than water immersion during insertion. The intriguing results should be subjected to further evaluation by additional RcTs to elucidate the mechanism of the pain-alleviating impact of the water method.

Identifiers

PMID22163081
PMCPMC3234695
OpenAlexW53557772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.