ArticlePloS one2011
Methicillin-susceptible ST398 Staphylococcus aureus responsible for bloodstream infections: an emerging human-adapted subclone?
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 81 citations in OpenAlex.
- Resistance to clinically important antibiotics and reduced susceptibility to disinfectants in the pandemic ST398 methicillin-susceptibleFrontiers in microbiology · 2026Article
- The Role of Prophage ϕSa3 in the Adaption ofAntibiotics (Basel, Switzerland) · 2024Article
- Genome Analysis of Methicillin-Resistant and Methicillin-SusceptibleMicroorganisms · 2023Article
- Strong Biofilm Formation and Low Cloxacillin Susceptibility in Biofilm-Growing CC398Microorganisms · 2022Article
- Dispersing and Sonoporating Biofilm-Associated Bacteria with Sonobactericide.Pharmaceutics · 2022Article
- Article
- In vitro and in vivo assessment of caprine origin Staphylococcus aureus ST398 strain UTCVM1 as an osteomyelitis pathogen.Frontiers in cellular and infection microbiology · 2022Article
- Molecular Characterization of Rifampicin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Disinfectant and Antimicrobial Susceptibility Studies ofMicroorganisms · 2021Article
- TheGenes · 2021Review
- Prevalence and Genetic Characteristics ofFrontiers in microbiology · 2021Article
- Whole-Genome Epidemiology and Characterization of Methicillin-SusceptibleFrontiers in microbiology · 2021Article
- Human Infection of Methicillin-SusceptibleMicroorganisms · 2020Review
- Epidemiology and risk factors of Staphylococcus aureus CC398 bone and joint infections.BMC infectious diseases · 2020Article
- Comparative Genomics of Plasmid-BearingFrontiers in microbiology · 2020Article
- Development and Application of a Prophage Integrase Typing Scheme for Group BFrontiers in microbiology · 2020Article
- Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Prevalence and characteristics of livestock-associated methicillin-susceptibleJournal of veterinary science · 2019Article
- Staphylococcus aureus nasal carriage among homeless population in Lisbon, Portugal.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Temperate Phages ofMicrobiology spectrum · 2019Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the course of an annual 3-month bloodstream infections (BSI) survey conducted during a four-year period in 31 healthcare institutions located in three noncontiguous French regions, we report 18 ST398 Staphylococcus aureus BSI. ST398 BSI incidence showed a seven-fold increase during the study period (0.002 per 1,000 patient days in 2007 vs. 0.014 in 2010). ST398 BSI isolates differed from the pig-borne multiresistant clone: 17/18 BSI isolates were methicillin susceptible and none was of t011, t034 or t108 pig-borne spa-types. ST398 BSI isolates had homogenous resistance patterns (15/18 with only Ery(r)) and prophagic content (all harboured the hlb-converting Sau3int phage). The clustering of BSI and pig-borne isolates by spa-typing and MLVA, the occurrence of Sau3int phage in BSI isolates and the lack of this phage in pig-borne isolates suggest that the emergence of BSI isolates could have arisen from horizontal transfer, at least of the Sau3int phage, in genetically diverse MSSA ST398 isolates. The acquisition of the phage likely plays a role in the increasing ability of the lysogenic ST398 isolates to colonize human. The mode of acquisition of the non pig-borne ST398 isolates by our 18 patients remains unclear. ST398 BSI were diagnosed in patients lacking livestock exposure and were significantly associated with digestive portals of entry (3/18 [16.7%] for ST398 vs. 19/767 [2.5%] for non ST398 BSI; p = .012). This raises the question of possible foodborne human infections. We suggest the need for active surveillance to study and control the spread of this human-adapted subclone increasingly isolated in the hospital setting.
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