ArticleThe Journal of experimental biology2012
Regulation of behaviorally associated gene networks in worker honey bee ovaries.
Article in The Journal of experimental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis.G3 (Bethesda, Md.) · 2023Article
- Conservation genomics reveals pesticide and pathogen exposure in the declining bumble bee Bombus terricola.Molecular ecology · 2021Article
- Societies to genes: can we get there from here?Genetics · 2021Article
- Social networks predict the life and death of honey bees.Nature communications · 2021Article
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- Missing Nurse Bees-Early Transcriptomic Switch From Nurse Bee to Forager Induced by Sublethal Imidacloprid.Frontiers in genetics · 2021Article
- Differences in the morphology, physiology and gene expression of honey bee queens and workers rearedBiology open · 2018Article
- Support for the reproductive ground plan hypothesis in a solitary bee: links between sucrose response and reproductive status.Proceedings. Biological sciences · 2017Article
- The Biogenic Amine Tyramine and its Receptor (AmTyr1) in Olfactory Neuropils in the Honey Bee (Frontiers in systems neuroscience · 2017Article
- Structure and function of gene regulatory networks associated with worker sterility in honeybees.Ecology and evolution · 2016Article
- Intensively Cultivated Landscape and Varroa Mite Infestation Are Associated with Reduced Honey Bee Nutritional State.PloS one · 2016Article
- Transcriptome Profile of the Asian Giant Hornet (Vespa mandarinia) Using Illumina HiSeq 4000 Sequencing: De Novo Assembly, Functional Annotation, and Discovery of SSR Markers.International journal of genomics · 2016Article
- Transcriptomic Signatures Mirror the Lack of the Fecundity/Longevity Trade-Off in Ant Queens.Molecular biology and evolution · 2015Article
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- Article
- Gene co-citation networks associated with worker sterility in honey bees.BMC systems biology · 2014Article
- How flies respond to honey bee pheromone: the role of the foraging gene on reproductive response to queen mandibular pheromone.Die Naturwissenschaften · 2014Article
- RNAi-mediated double gene knockdown and gustatory perception measurement in honey bees (Apis mellifera).Journal of visualized experiments : JoVE · 2013Article
- Genetics of reproduction and regulation of honeybee (Apis mellifera L.) social behavior.Annual review of genetics · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Several lines of evidence support genetic links between ovary size and division of labor in worker honey bees. However, it is largely unknown how ovaries influence behavior. To address this question, we first performed transcriptional profiling on worker ovaries from two genotypes that differ in social behavior and ovary size. Then, we contrasted the differentially expressed ovarian genes with six sets of available brain transcriptomes. Finally, we probed behavior-related candidate gene networks in wild-type ovaries of different sizes. We found differential expression in 2151 ovarian transcripts in these artificially selected honey bee strains, corresponding to approximately 20.3% of the predicted gene set of honey bees. Differences in gene expression overlapped significantly with changes in the brain transcriptomes. Differentially expressed genes were associated with neural signal transmission (tyramine receptor, TYR) and ecdysteroid signaling; two independently tested nuclear hormone receptors (HR46 and ftz-f1) were also significantly correlated with ovary size in wild-type bees. We suggest that the correspondence between ovary and brain transcriptomes identified here indicates systemic regulatory networks among hormones (juvenile hormone and ecdysteroids), pheromones (queen mandibular pheromone), reproductive organs and nervous tissues in worker honey bees. Furthermore, robust correlations between ovary size and neuraland endocrine response genes are consistent with the hypothesized roles of the ovaries in honey bee behavioral regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.